Type 2 diabetes mellitus and cognition - An understudied issue in women's health
Type 2 diabetes mellitus and cognition - An understudied issue in women's health
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DOI：
10.1016/s0022-3999(02)00523-8
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发表时间：
2003-02-01
影响因子：
4.7
通讯作者：
Shumaker, SA
中科院分区：
文献类型：
--
作者：
Coker, LH;Shumaker, SA
简介：糖尿病是一种常见的慢性病，影响着大约1600万美国人，女性比男性略多见。来自人群研究的数据表明，患有糖尿病的女性患心血管疾病的风险更高，心血管疾病是女性死亡的主要原因，也是认知能力下降的独立风险因素。纵向流行病学研究报告了糖尿病和血管性痴呆之间的联系，但关于糖尿病和阿尔茨海默氏症之间的联系的数据相互矛盾。自20世纪80年代以来，2型糖尿病是否对认知功能产生了独立于痴呆症的影响，受到了极大的关注，但这个问题仍然没有得到解决。方法：严格回顾文献，通过神经心理学(NP)测试对2型糖尿病患者和对照组/非糖尿病对照组的认知功能进行测量。结果：在32项报告了2型糖尿病对非痴呆性中老年人认知影响的研究中，30项研究样本包括女性，两项研究专门针对女性。在包括女性的研究中，20名(67%)报告说，患有2型糖尿病的参与者在一项或多项NP测试中的表现比那些没有糖尿病的人更差，这导致作者得出结论，糖尿病与认知功能障碍呈正相关。结论：由于有足够数量的女性来按性别报告研究结果的研究为数不多，人们对2型糖尿病对女性认知的影响知之甚少。至关重要的是，关于2型糖尿病和认知功能的研究应将女性包括在足以检查性别影响的人数中。讨论涉及需要进一步研究的妇女特有的问题。(C)2003 Elsevier Science Inc.保留所有权利。
Introduction: Diabetes is a common chronic illness, affecting approximately 16 million Americans, and is slightly more common in women than men. Data from population studies demonstrate that women with diabetes are at greater risk for cardiovascular disease, the leading cause of death among women and an independent risk factor for cognitive decline. Longitudinal epidemiologic studies report an association between diabetes mellitus and vascular dementia, but conflicting data on the association between diabetes and Alzheimer's dementia. Whether type 2 diabetes has an effect on cognitive function, independent of dementia, has received much attention since the 1980s, but the question remains unresolved. Method: The literature was rigorously reviewed for studies in which cognitive functioning was measured with neuropsychological (NP) tests in participants with type 2 diabetes and a control/comparison group without diabetes. Results: Of 32 studies that reported the effects of type 2 diabetes on cognition in nondemented middle-aged and older adults, 30 included women in their samples, and two focused exclusively on women. Of studies that included women, 20 (67%) reported that participants with type 2 diabetes performed more poorly than those without diabetics on one or more NP tests, leading the authors to conclude that diabetes is positively associated with cognitive dysfunction. Conclusions: Owing to the small number of studies with adequate numbers of women to report findings by gender, little is known about the effect of type 2 diabetes on cognition in women. It is critical that studies on type 2 diabetes and cognitive functioning be designed to include women in numbers adequate for examination of gender effects. The discussion addresses issues specific to women that warrant further research. (C) 2003 Elsevier Science Inc. All rights reserved.