Treat to Target: A Proposed New Paradigm for the Management of Crohn's Disease
Treat to Target: A Proposed New Paradigm for the Management of Crohn's Disease
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DOI：
10.1016/j.cgh.2013.09.006
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发表时间：
2015-06-01
影响因子：
12.6
通讯作者：
Sandborn, William J.
中科院分区：
文献类型：
--
作者：
Bouguen, Guillaume;Levesque, Barrett G.;Sandborn, William J.
克罗恩病的传统管理是基于渐进的、逐步的治疗强化，并根据症状重新评估反应，不能改善克罗恩病的长期结局，并使患者面临肠损伤的风险。新疗法的引入和类风湿性关节炎治疗新方法的开发为患者带来了更好的结果。其中最突出的是“靶向治疗”战略，该战略的基础是通过使用客观的临床和生物学结果措施定期评估疾病活动，并随后调整治疗。这种方法是对高危患者早期干预概念的补充。这篇综述评估了目前关于这一主题的文献，并提出了一个定义的概念，治疗克罗恩病的目标。
The traditional management of Crohn's disease, which is based on progressive, step-wise treatment intensification with re-evaluation of response according to symptoms, does not improve long-term outcomes of Crohn's disease and places patients at risk for bowel damage. The introduction of novel therapies and the development of new approaches to treatment in rheumatoid arthritis led to better outcomes for patients. Prominent among these is a "treat to target" strategy that is based on regular assessment of disease activity by using objective clinical and biological outcome measures and the subsequent adjustment of treatments. This approach is complementary to the concept of early intervention in high-risk patients. This review evaluates current literature on this topic and proposes a definition for the concept of treating to targets for Crohn's disease.