Iron and zinc exploitation during bacterial pathogenesis.
Iron and zinc exploitation during bacterial pathogenesis.
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DOI：
10.1039/c5mt00170f
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Maresso AW
中科院分区：
文献类型：
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作者：
Ma L;Terwilliger A;Maresso AW
古代细菌起源于富含金属的环境。数十亿年的进化引导这些微小的单细胞生物利用金属的多种特性来催化化学反应和生物反应。结果是一个完整的金属组蛋白质，使用金属辅助因子来促进关键的细胞过程，从能量的产生到DNA的复制。这方面的两种关键金属是铁和锌，这两种金属在地球上都很丰富，但在人类宿主中却不容易获得。相反，致病菌必须采用聪明的方法来获取这些金属。在这篇综述中，我们描述了许多优雅的方式，这些细菌挖掘，调节和工艺使用两种关键金属（铁和锌）来建立一个毒力库，甚至挑战最复杂的免疫反应。
Ancient bacteria originated from metal-rich environments. Billions of years of evolution directed these tiny single cell creatures to exploit the versatile properties of metals in catalyzing chemical reactions and biological responses. The result is an entire metallome of proteins that use metal co-factors to facilitate key cellular process that range from the production of energy to the replication of DNA. Two key metals in this regard are iron and zinc, both abundant on Earth but not readily accessible in a human host. Instead, pathogenic bacteria must employ clever ways to acquire these metals. In this review we describe the many elegant ways these bacteria mine, regulate, and craft the use of two key metals (iron and zinc) to build a virulence arsenal that challenges even the most sophisticated immune response.