Nucleus accumbens core lesions enhance two-way active avoidance.
Nucleus accumbens core lesions enhance two-way active avoidance.
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DOI：
10.1016/j.neuroscience.2013.11.028
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发表时间：
2014-01-31
期刊：
影响因子：
3.3
通讯作者：
Roesch MR
中科院分区：
文献类型：
--
作者：
Lichtenberg NT;Kashtelyan V;Burton AC;Bissonette GB;Roesch MR
研究伏隔核核心(NAC)的大部分工作都集中在与食欲结果引导的行为相关的功能上。这些研究指出，NAC对于激励行为以获得理想的结果至关重要。例如，我们最近发现，NAC的病变损害了一项奖赏导向决策任务的表现，该任务要求大鼠在不同价值的奖赏之间做出选择。不幸的是，当预测到令人厌恶的结果时，人们对NAC在激励行为方面所起的作用知之甚少。为了解决这个问题，我们询问NAC病变是否影响双向主动回避任务的表现，在该任务中，大鼠必须学会在行为训练盒中来回穿梭，以避免听觉音调预测的足部电击。尽管双侧NAC损毁最初损害了奖赏引导决策，但我们发现相同的损毁改善了双向主动回避的习得和保持。
The majority of work examining nucleus accumbens core (NAc) has focused on functions pertaining to behaviors guided by appetitive outcomes. These studies have pointed to NAc as being critical for motivating behavior toward desirable outcomes. For example, we have recently shown that lesions of NAc impaired performance on a reward-guided decision-making task that required rats to choose between differently valued rewards. Unfortunately, much less is known about the role that NAc plays in motivating behavior when aversive outcomes are predicted. To address this issue we asked if NAc lesions impact performance on a two-way active avoidance task in which rats must learn to shuttle back and forth in a behavioral training box in order to avoid a footshock predicted by an auditory tone. Although bilateral NAc lesions initially impaired reward-guided decision-making, we found that the same lesions improved acquisition and retention of two-way active avoidance.