Glycine betaine, a beer component, protects radiation-induced injury
Glycine betaine, a beer component, protects radiation-induced injury
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DOI：
10.1269/jrr.46.117
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发表时间：
2005-03-01
影响因子：
2
通讯作者：
Kojima, S
中科院分区：
文献类型：
--
作者：
Monobe, M;Uzawa, A;Kojima, S
人全血暴露于（CS）-C-137 γ射线或50 keV/pm碳离子在存在或不存在甘氨酸甜菜碱，啤酒成分在体外。经4戈伊γ射线或碳离子照射后，甘氨酸甜菜碱可显著降低人淋巴细胞染色体畸变的双着丝粒数（p0.05）。甜菜碱对γ射线和碳离子的最大保护率分别为37%和20%。14周龄的C3 H/He雌性小鼠在用γ射线或50 keV/pm碳离子全身照射前15 min接受甘氨酸甜菜碱的腹腔注射。甘氨酸甜菜碱显著（p 0.05）增加了γ射线或碳离子照射小鼠的存活率。总之，甘氨酸甜菜碱是一种有效的保护剂，可以对抗低和高LET辐射引起的损伤。
Human whole-blood was exposed to (CS)-C-137 γ-rays or 50 keV/pm carbon ions in the presence or absence of glycine betaine, a beer component in vitro. The dicentrics of chromosome aberrations in human lymphocytes were significantly (p < 0.05) reduced by glycine betaine after irradiation with 4 Gy of either γ-rays or carbon ions. The maximum protection by glycine betaine for γ-rays or carbon ions was 37% and 20%, respectively. C3H/He female mice, aged 14 weeks, received an i.p. injection of glycine betaine 15 min before whole-body irradiation with γ-rays or 50 keV/pm carbon ions. Glycine betaine significantly (p < 0.05) increased the percent survival of irradiated mice with either y-rays or carbon ions.In conclusion, glycine betaine is a potent protector against damages caused by low- and high-LET radiation.