ESTRADIOL AND PROGESTERONE RECEPTORS IN HUMAN-ENDOMETRIUM - NORMAL AND ABNORMAL MENSTRUAL CYCLES AND EARLY-PREGNANCY
ESTRADIOL AND PROGESTERONE RECEPTORS IN HUMAN-ENDOMETRIUM - NORMAL AND ABNORMAL MENSTRUAL CYCLES AND EARLY-PREGNANCY
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DOI：
10.1016/0002-9378(80)91018-2
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发表时间：
1980-01-01
影响因子：
9.8
通讯作者：
EYCHENNE, B
中科院分区：
文献类型：
--
作者：
LEVY, C;ROBEL, P;EYCHENNE, B
在排卵前阶段，胞质雌二醇[E_2]受体部位没有变化，而核受体部位增加了一倍以上。在分泌期的早期，细胞质中的E2受体位置减少，而核位置的减少发生在较晚的时候。胞浆孕酮[P]受体在排卵前期增加一倍以上，在排卵后立即显著减少，此时核受体浓度最高。因此，E_2和P受体的细胞总浓度在分泌后期最低。仅在增生期与血浆E_2浓度呈正相关。分泌期胞质P受体浓度与17β-羟基类固醇氧化还原酶活性呈负相关。在无排卵周期中，E_2和P受体浓度较高，与增殖期晚期相似。黄体功能不全的特征是E2受体浓度非常低。妊娠早期(妊娠8-10wk)子宫内膜以大量的P受体为特征，超过月经周期的任何时期。
During the preovulatory phase the cytoplasmic estradiol [E2] receptor sites do not change while the nuclear receptor sites more than double. Cytoplasmic E2 receptor sites decrease very early in the secretory phase, whereas the decrease in nuclear sites occurs later. Cytoplasmic progesterone [P] receptor sites more than double during the preovulatory phase and show a large decrease immediately after ovulation, when the concentration of nuclear receptor is at its highest. Thus the total cellular concentrations of both E2 and P receptors are lowest in the late secretory phase. They are positively correlated with the concentration of plasma E2 only during the proliferative phase. The concentration of cytoplasmic P receptor is negatively correlated with 17.beta.-hydroxysteroid oxidoreductase activity during the secretory phase. In anovulatory cycles the concentrations of E2 and P receptors are high, similar to those of the late proliferative phase. Luteal insufficiency is characterized by a very low concentration of E2 receptor. Early pregnancy endometrium (8-10 wk gestation) is characterized by a large concentration of P receptor, exceeding those of any period of the menstrual cycle.