Anxiety is functionally segregated within the septo-hippocampal system
Anxiety is functionally segregated within the septo-hippocampal system
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DOI：
10.1016/j.brainres.2003.10.065
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发表时间：
2004-03-19
期刊：
影响因子：
2.9
通讯作者：
Treit, D
中科院分区：
文献类型：
--
作者：
Degroot, A;Treit, D
先前的病变研究表明，间隔海马系统与恐惧和焦虑有关。在这项研究中，我们检查了大鼠隔海马系统各个方面的暂时神经元抑制对焦虑的影响。输注河豚毒素（TTX）用于诱导穹窿伞、内侧隔膜、背侧海马和腹侧海马的可逆性损伤。为了评估焦虑，我们使用了高架十字迷宫和冲击探针埋藏测试。高架十字迷宫中焦虑的减少由开放式探索的增加表明，而冲击探针埋藏测试中焦虑的减少则由埋藏行为减少或与冲击探针接触的增加表明。结果表明，抑制间隔海马系统会诱导不同性质的位点特异性抗焦虑作用。穹窿伞的河鲀毒素损伤增加了大鼠的张开臂探索和电击次数，但对埋藏行为没有影响。间隔和腹侧海马病变均增加了张臂探查并减少了埋藏行为，但对探针冲击的次数没有影响。最后，背侧海马的 TTX 损伤增加了大鼠受到电击的次数，但不影响张臂活动或埋葬行为。神经解剖学研究表明，背侧海马 TTX 损伤对电击次数的影响不太可能是由杏仁核介导的。总的来说，数据表明，特定焦虑反应的控制在功能上是在隔海马系统的不同方面分离的。 (C) 2004 Elsevier B.V. 保留所有权利。
Previous lesion studies have suggested that the septal-hippocampal system is involved in fear and anxiety. In this study we examined the effects on anxiety of temporary neuronal inhibition of various aspects of the septo-hippocampal system in rats. Infusions of tetrodotoxin (TTX) were used to induce reversible lesions in the fimbria fornix, medial septum, dorsal hippocampus, and ventral hippocampus. To assess anxiety we used the elevated plus-maze and the shock-probe burying tests. A reduction in anxiety in the elevated plus-maze is indicated by increased open ann exploration, whereas a reduction in anxiety in the shock-probe burying test is indicated by decreased burying behavior or increased contacts with the shock-probe. The results suggested that inhibition of the septal-hippocampal system induced site-specific anxiolytic effects that vary in nature. Tetrodotoxin lesions of the fimbria fornix increased both open arm exploration and the number of shocks taken by the rats, while having no effect on burying behavior. Both septal and ventral hippocampal lesions increased open arm exploration and decreased burying behavior, but had no effect on the number of probe shocks. Finally, TTX lesions of the dorsal hippocampus increased the number of shocks taken by the rats, but did not affect open arm activity or burying behavior. Neuroanatomical studies indicated that the effect on the number of shocks induced by dorsal hippocampal TTX lesions was not likely mediated by the amygdala. Collectively, the data suggest that the control of specific anxiety reactions is functionally segregated within different aspects of the septo-hippocampal system. (C) 2004 Elsevier B.V. All rights reserved.