Antianginal efficiency of nifedipine with and without a beta‐blocker, studied with exercise test. A double‐blind, randomized subacute study
Antianginal efficiency of nifedipine with and without a beta‐blocker, studied with exercise test. A double‐blind, randomized subacute study
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通过运动试验研究硝苯地平联合或不联合β受体阻滞剂的抗心绞痛功效。
DOI：
10.1002/clc.4960020306
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发表时间：
1979
影响因子：
2.7
通讯作者：
L. Orö
中科院分区：
文献类型：
--
作者：
L. Ekelund;L. Orö
21例患者，平均年龄60.3岁，早期接受β受体阻滞剂治疗的稳定型心绞痛患者，通过标准化的运动试验来评估硝苯地平单独和联合β受体阻滞剂的作用。第一次运动试验在患者常用的受体阻滞剂治疗3周后进行。在此之后，患者在硝苯地平和安慰剂的双盲交叉试验后进行了两次测试。患者随后服用硝苯地平10mg，每日3次或安慰剂治疗3周，然后进行运动试验。在第4期（3周），患者服用硝苯地平，10毫克，每日3次，以及他们常用的受体阻滞剂，然后进行最后的运动试验。
Twenty‐one patients, mean age 60.3 years, with stable angina pectoris earlier treated with beta‐blockers, were investigated with standardized exercise tests to evaluate the action of nifedipine alone and in combination with a beta‐blocker. The first exercise test was performed 3 weeks after treatment with the patient's usual beta‐blocker. Following this, the patients were tested twice after a double‐blind cross‐over 3‐week trial with nifedipine and placebo. The patients were subsequently treated for 3 weeks with nifedipine 10 mg 3 times daily or placebo and then performed an exercise test. During the 4th period of 3 weeks the patients took a combination of nifedipine, 10 mg 3 times daily, and their usual beta‐blocker and then performed the final exercise test.