Associations Between Sleep Quality and Migraine Frequency: A Cross-Sectional Case-Control Study.
Associations Between Sleep Quality and Migraine Frequency: A Cross-Sectional Case-Control Study.
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DOI：
10.1097/md.0000000000003554
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发表时间：
2016-04
期刊：
影响因子：
1.6
通讯作者：
Yang FC
中科院分区：
文献类型：
--
作者：
Lin YK;Lin GY;Lee JT;Lee MS;Tsai CK;Hsu YW;Lin YZ;Tsai YC;Yang FC
偏头痛与睡眠障碍有关。睡眠质量和偏头痛频率之间的关系尚未确定。本研究旨在调查低频率、中频率、高频率和慢性偏头痛患者的睡眠障碍，有无先兆，以及控制良好的混杂变量。这项横断面对照研究包括来自台湾头痛门诊的357名受试者。采用标准化问卷调查收集所有参与者的人口统计学、偏头痛、睡眠、抑郁、焦虑和不宁腿综合征特征。根据偏头痛发作频率将患者分为4组：每月偏头痛发作14天，每月偏头痛发作5 ~ 8天，每月偏头痛发作9 ~ 14天，每月偏头痛发作>14天。采用匹兹堡睡眠质量指数（PSQI）及各亚组项目评价睡眠质量。偏头痛频率和睡眠质量之间的关系采用多变量线性回归和逻辑回归进行了研究。PSQI总分在高频率偏头痛患者中最高（10.0 ± 3.4），在对照组中最低（7.0 ± 3.4），具有显著趋势分析（趋势P = 0.006）。 偏头痛频率对“30分钟内无法入睡”（P <0.001）、“半夜或清晨醒来”（P< 0.001）、“噩梦”（P = 0.001）、“疼痛”（P = 0.004）和“睡眠质量”（P <0.001）有独立影响。 结果显示偏头痛频率在有先兆亚组（趋势P = 0.008）和无先兆亚组（趋势P = 0.011）中的影响。 偏头痛频率高与睡眠质量差和睡眠质量差的患病率较高有关。这些关联发生在有先兆和无先兆的偏头痛中。
Migraine has been associated with sleep disturbances. Relationship between sleep quality and migraine frequency is yet to be determined. The present study aimed to investigate sleep disturbances among low-frequency, moderate-frequency, high-frequency, and chronic migraineurs, with and without auras, with well-controlled confounding variables. This cross-sectional controlled study included 357 subjects from an outpatient headache clinic in Taiwan. Standardized questionnaires were utilized to collect demographic, migraine, sleep, depression, anxiety, and restless leg syndrome characteristics in all participants. According to frequency of migraine attacks, patients were divided into 4 groups: with 1 to 4 migraine days per month, 5 to 8 migraine days in a month, 9 to 14 migraine days in a month, and >14 migraine days per month. The Pittsburgh Sleep Quality Index (PSQI) and subgroup items were used to evaluate sleep quality. The association between migraine frequency and sleep quality was investigated using multivariable linear regression and logistic regression. The PSQI total score was highest in patients with high frequent migraine (10.0 ± 3.4) and lowest in controls (7.0 ± 3.4) with a significant trend analysis (P for trend = 0.006). Migraine frequency had an independent effect on the items “Cannot get to sleep within 30 minutes” (P < 0.001), “Wake up in the middle of the night or early morning” (P < 0.001), “Bad dreams” (P = 0.001), “Pain” (P = 0.004), and “Quality of sleep” (P < 0.001). The result showed the effect of migraine frequency in both the aura-present (P for trend = 0.008) and the aura-absent subgroups (P for trend = 0.011). High migraine frequency correlates with poor sleep quality and a higher prevalence of poor sleepers. These associations occur in migraine with aura and without aura.