Relationships of sex hormone levels to dependence in activities of daily living in the frail elderly
Relationships of sex hormone levels to dependence in activities of daily living in the frail elderly
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DOI：
10.1016/s0378-5122(01)00208-0
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发表时间：
2001-08-25
期刊：
影响因子：
4.9
通讯作者：
Zumoff, B
中科院分区：
文献类型：
--
作者：
Breuer, B;Trungold, S;Zumoff, B
目的：我们进行了这项研究，以确定日常生活活动（ADL）和雌酮，睾酮，雄烯二酮，脱氢表雄酮（DHEA）的血液水平的依赖性之间的关系。对这个问题知之甚少。方法：对370名养老院居民进行横断面调查。1997年和1998年抽取的血液标本中的激素水平与病历中记录的ADL依赖程度相关。结果如下：由于多重比较，当雄性的P值小于或等于0.017，雌性的P值小于或等于0.0125时，相关性被认为是显著的。在男性中，以下各项呈负相关：睾酮水平与转移和进食的依赖性;雌酮与进食和汇总ADL指数;雄烯二酮与排便和汇总ADL指数（在所有情况下，r = -0.4，P = 0.007-0.015）。相反的趋势存在睾酮水平和依赖性的流动性和总结ADL指数。雄烯二酮与进食的关系（r = -0.3，P = 0.030-0.055）。在女性中，以下是直接相关的：雌酮水平与依赖的移动，移动，转移，和一个总结ADL指数;和DHEA与转移和一个总结ADL指数（r = 0.2 - 0.3，P = 0.0001 - 0.01）。雌酮与进食、DHEA与排便之间存在趋势（r = 0.1 ~ 0.2，P = 0.04）。结论：在男性居民中，较高的性激素水平与较好的ADL表现相关。在女性中，情况正好相反。虽然需要进一步的研究来阐明这些关系，但我们的结果和其他人的最新发现表明，老年女性的性激素作用与年轻人群不同。还提出了一种可能的应力相关机制。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Objectives: We undertook this nursing home study in order to determine the relationships between dependency in activities of daily living (ADL) and blood levels of estrone, testosterone, androstenedione, and dehydroepiandrosterone (DHEA). Little is known about this issue. Methods: cross-sectional study of 370 nursing home residents. Hormone levels in blood specimens drawn in 1997 and 1998 were correlated with degree of ADL dependency recorded in medical charts. Results: Because of multiple comparisons associations were deemed significant for P-values less than or equal to0.017 for mates and less than or equal to0.0125 for females. In males, the following were inversely related: testosterone levels with dependency in transferring and eating; estrone with eating and a summary ADL index; and androstenedione with toileting and a summary ADL index (in all cases, r = -0.4; P = 0.007-0.015). Inverse trends existed between testosterone levels and dependency in mobility and a summary ADL index. and androstenedione and eating (in all cases r = -0.3; P = 0.030-0.055). Among females the following were directly related: estrone levels with dependence in mobility, toileting, transferring, and a summary ADL index; and DHEA with transferring and a summary ADL index (r = 0.2 - 0.3, P = 0.0001 - 0.01). Trends existed between estrone and eating, and DHEA and toileting (r = 0.1 - 0.2, P = 0.04). Conclusion: In male residents, higher sex hormone levels are associated with better ADL performance. Among females the opposite is true. While further studies are needed to elucidate these relationships, our results and recent findings of others suggest sex hormone actions in older women differ from those in younger populations. A possible stress-related mechanism is also presented. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.