Cardioactive substances that prolong the open state of sodium channels.
Cardioactive substances that prolong the open state of sodium channels.
复制标题
延长钠通道开放状态的心脏活性物质。
DOI：
10.1007/bfb0030502
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Peter Honerjäger
中科院分区：
文献类型：
--
作者：
Peter Honerjäger
现在人们认识到，植物或动物进化出的许多有毒物质是通过干扰神经和肌肉细胞的兴奋过程而起作用的。具体地说，这些化合物改变了启动动作电位的膜对钠离子(PNA)的快速和瞬时的通透性增加。根据毒素改变钠通透机制或钠通道的一般模式，可将其区分为两类。第一类物质，包括河豚毒素(TTX)和岩藻毒素(STX)，阻止钠离子通过钠通道流动。第二组毒素维持钠通道的开放形式，从而延长钠离子流入细胞的时间。这类物质包括生物碱(西韦拉特生物碱、巴曲毒素、乌头碱)、二萜类灰色毒素以及来自蝎子、海葵和珊瑚的多肽，并含有已知的最有效和最特异的物质，可增加可兴奋膜的钠通透性。毒素
It is now recognized that many toxic substances evolved by plants or animals act by interfering with the excitation process of nerve and muscle cells. Specifically, these compounds alter the rapid and transient increase in membrane permeability to Na ions (PNa), that initiates the action potential. According to the general mode by which toxins modify the Na permeability mechanism, or Na channels, two groups can be distinguished. The first group of substances, including tetrodotoxin (TTX) and saxitoxin (STX), blocks the flow of Na ions through Na channels. The second group of toxins maintains an open form of the Na channel, thereby prolonging the time during which Na ions flow into the cell. This group comprises alkaloids (ceveratrum alkaloids, batrachotoxin, aconitine), the diterpenoid grayanotoxins, and polypeptides from scorpions, sea anemones and coral and contains the most potent and most specific substances known to increase the Na permeability of excitable membranes. Toxins