Arsenic trioxide at conventional dosage does not aggravate hemorrhage in the first-line treatment of adult acute promyelocytic leukemia.
Arsenic trioxide at conventional dosage does not aggravate hemorrhage in the first-line treatment of adult acute promyelocytic leukemia.
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DOI：
10.1111/ejh.13018
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Jian-Qing Mi
中科院分区：
文献类型：
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作者：
Wen Cui;Jin Wang;Rui-Min Nie;Ling-Ling Zhao;Meng-Qing Gao;Hong-Ming Zhu;Li Chen;Jiong Hu;Jun-Min Li;Zhi-Xiang Shen;Zhen-Yi Wang;Sai-Juan Chen;Zhu Chen;Kan-Kan Wang;Xiao-Dong Xi;Jian-Qing Mi
OBJECTIVES:.The Arsenic trioxide (ATO) plus all-trans retinoic acid (ATRA) therapy has demonstrated a tremendous success in the first-line treatment of acute promyelocytic leukemia (APL). Actually, early death (ED) is currently thought as a major challenge in APL. ATO has been reported to inhibit platelet function in vitro, whether it increases the ED rate by exacerbating the hemorhagic symptoms remains to be investigated...METHODS:.Effects of ATO on platelet aggragation and adhesion was evaluated in vitro and in thirty-two complete remission (CR) and four newly-diagnosed APL patients. Furthermore, concentrations of plasma total arsenic was monitored in APL patients via ICP-MS...RESULTS:.The inhibition of platelet function, either aggregation or adhesion, did occur in vitro when the concentration of ATO reached 2 μmol/L. However, in CR APL pateients receiving ATO with normal platelet count, the platelets responded normally when being activated and so did those in the newly-diagnosed patients with thrombocytopenia. Our data further showed that the conventional dosage of ATO reached a plasma concentration substantially below the required concentration to inhibit platelets...CONCLUSIONS:.In the first-line treatment of APL, the use of ATO is safe and effective, and does not compromise the hemostatic potential that may eventually increase ED rate. This article is protected by copyright. All rights reserved.
