Ubiquitin signaling in immune responses.
Ubiquitin signaling in immune responses.
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DOI：
10.1038/cr.2016.40
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发表时间：
2016-04
期刊：
影响因子：
44.1
通讯作者：
Sun SC
中科院分区：
文献类型：
--
作者：
Hu H;Sun SC
泛素化已成为调节多种生物过程（包括免疫功能的不同方面）中信号转导的重要机制。泛素化调节模式识别受体信号传导，其介导先天免疫应答和启动适应性免疫应答所需的树突状细胞成熟。泛素化还调节T细胞的发育、活化和分化，从而维持对病原体的有效适应性免疫应答和对自身组织的免疫耐受。像磷酸化一样，泛素化是一个可逆的反应，由泛素连接酶和去泛素化酶的相反作用紧密控制。去调节的泛素化事件与免疫性疾病相关，包括自身免疫性疾病和炎性疾病。
Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological processes, including different aspects of immune functions. Ubiquitination regulates pattern-recognition receptor signaling that mediates both innate immune responses and dendritic cell maturation required for initiation of adaptive immune responses. Ubiquitination also regulates the development, activation, and differentiation of T cells, thereby maintaining efficient adaptive immune responses to pathogens and immunological tolerance to self-tissues. Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. Deregulated ubiquitination events are associated with immunological disorders, including autoimmune and inflammatory diseases.