Single vs multiple somatic nerve crushes in the rat.
Single vs multiple somatic nerve crushes in the rat.
复制标题
大鼠中的单个与多个躯体神经挤压。
DOI：
10.1016/0006-8993(87)90709-8
复制
发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Coggeshall,RE
中科院分区：
文献类型：
--
作者：
Jenq,CB;Coggeshall,RE
神经病变改变了对后续病变的再生反应。一些修改可能是有用的。为了增加我们对这些改变的理解，本研究测定了大鼠坐骨神经远端和2个较小分支（腓肠肌内侧神经和腓肠神经）中有髓鞘和无髓鞘轴突的数量，分别在单次或最后3次挤压大鼠坐骨神经后8周和9个月。对于有髓鞘的轴突，在单次和三次挤压后，坐骨神经及其小分支的挤压远端明显且成比例地增加。这些增加的轴突持续存在。我们解释这些数据表明，一些再生的髓鞘轴突在病变部位分支，没有分支进入支神经，然后可能在周围找到附着物。如果这是真的，单次或多次粉碎可能在需要增加存活神经元进程数量的情况下有用。单次挤压和三次挤压的主要区别是，髓鞘轴突在三次挤压后增加更多，在三次挤压后8周至9个月内显著增加，而单次挤压后则没有。因此，如果将单次挤压后的再生与多次挤压后的类似再生进行比较，不仅髓鞘轴突的数量，而且髓鞘形成过程的时间似乎也会发生变化。没有髓鞘的轴突不能像有髓鞘的轴突那样再生。主要的区别是，在单次或多次挤压后，无髓鞘轴突数量在长期再生后恢复正常。然而，再生模式不同，腓肠肌内侧神经在3次挤压和单次挤压后，轴突产生过剩，随后恢复正常水平，而坐骨神经和腓肠神经在单次挤压后，轴突数量缓慢上升至正常水平。因此，在第一种情况下，似乎有过多的轴突分支，随后可能由于缺乏周围连接的形成而失去，而在第二种情况下，没有分支的证据，只是稳定地增加到正常水平。
Nerve lesions modify regenerative responses to subsequent lesions. Some of the modifications might be useful. To increase our understanding of these modifications, the present study determines myelinated and unmyelinated axon numbers in the distal part of rat sciatic nerve and in 2 smaller branches, the nerve to the medial gastrocnemius muscle and the sural nerve, 8 weeks and 9 months following either single or the last of 3 crushes to the rat sciatic nerve. For myelinated axons, there is a significant and proportional increase distal to the crush in the sciatic nerve and in its smaller tributaries following both single and triple crushes. These increased axons persist. We interpret these data to indicate that some of the regenerating myelinated axons branch at the site of lesion, pass without branching into the tributary nerves, and then presumably find attachments at the periphery. If true, single or multiple crushes might be useful in conditions where it would be desirable to increase numbers of processes from surviving neurons. The major differences between single and triple crushes are that myelinated axons are increased more after triple crush and increase significantly between 8 weeks and 9 months after triple crush but not after single crush. Thus not only myelinated axon numbers, but the timing of the myelination process seems to change if regeneration following single crush is compared to similar regeneration following multiple crushes. Unmyelinated axons do not regenerate in the same way as the myelinated axons. The major difference is that unmyelinated axon numbers return to normal after long-term regeneration following either single or multiple crushes. The regeneration pattern differs, however, in that after 3 crushes and after single crush for the nerve to the medial gastrocnemius muscle, there is overproduction of axons followed by a return to normal levels, whereas for the sciatic and sural nerves after single crush, axon numbers slowly rise to normal levels. In the first case, therefore, there seems to be excess axon branching followed by a loss presumably due to the lack of formation of peripheral connections, whereas for the second case, there is no evidence of branching but only a steady increase to normal levels.