Metabolomics dataset of PPAR-pan treated rat liver.
Metabolomics dataset of PPAR-pan treated rat liver.
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DOI：
10.1016/j.dib.2016.05.002
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发表时间：
2016-09
期刊：
影响因子：
1.2
通讯作者：
Griffin JL
中科院分区：
文献类型：
--
作者：
Ament Z;West JA;Stanley E;Li X;Ashmore T;Roberts LD;Wright J;Nicholls AW;Griffin JL
这篇文章包含质谱（MS）数据，其研究了作为三重过氧化物酶体增殖物激活受体（PPAR-pan）激动剂GW 625019在肝脏中的作用的小分子变化，如手稿中所述（Ament等人，2016年）。使用气相色谱-质谱法（GC-MS）测量样品的总脂肪酸含量，并使用液相色谱-质谱法（LC-MS）测量完整脂质、肉毒碱和选定的水性代谢物和类二十烷酸。数据文件包括已鉴别代谢物的Excel（Microsoft，WA，USA）电子表格及其总脂肪酸、肉毒碱、水性代谢物和类二十烷酸的面积比值，其中分析物的强度归一化为内标物的强度。在开放分析完整脂质数据的情况下，Excel文件包含保留时间和质荷比对的面积比值;同样，通过归一化至内标物的强度计算面积比值。应该注意的是，几种代谢变化可能是间接的（继发性、三级和随后的变化）。
This article contains mass spectrometry (MS) data investigating small molecule changes as an effect of a triple peroxisome proliferator-activated receptor (PPAR-pan) agonist GW625019 in the liver as described in the manuscript (Ament et al., 2016). Samples were measured using gas chromatography-mass spectrometry (GC–MS) for total fatty acid content, and liquid chromatography-mass spectrometry (LC–MS) to measure intact lipids, carnitines and selected aqueous metabolites and eicosanoids. Data files comprise of Excel (Microsoft, WA, USA) spreadsheets of identified metabolites and their area ratio values for total fatty acids, carnitines, aqueous metabolites, and eicosanoids where the intensity of the analytes were normalised to the intensity of the internal standard. In the case of open profiling intact lipid data, the Excel file contains area ratio values of retention time and mass to charge ratio pairs; again, the area ratio values were calculated by normalising to the intensity of the internal standard. It should be noted that several metabolic changes are potentially indirect (secondary, tertiary and ensuing changes).