Epidemiologic study of drinking water chlorination and Wisconsin female cancer mortality.
Epidemiologic study of drinking water chlorination and Wisconsin female cancer mortality.
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饮用水氯化和威斯康星州女性癌症死亡率的流行病学研究。
DOI：
10.1093/jnci/67.6.1191
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
A. Tsiatis
中科院分区：
文献类型：
--
作者：
T. Young;M. Kanarek;A. Tsiatis
通过使用基于死亡证明的病例对照研究设计，对威斯康星州白色女性的胃肠道、泌尿道、脑、肺和乳腺癌死亡率与饮用水三卤甲烷暴露之间的关联进行了研究，该研究通过过去20年水源的平均每日氯剂量进行估计。从1972年至1977年28个县的死亡率记录中，共收集了8,029例癌症死亡和8,029例对照（非癌症死亡），这些死亡与居住县、死亡年份和年龄相匹配。数据的特点和处理的市政供水的住宅的情况下，控制，从问卷调查发送到202个自来水厂与样本相关的水主管。通过使用逻辑回归分析，与高，中，低氯剂量的水相比，未氯化的水暴露的特定地点的癌症死亡的优势比进行了测定;控制变量是城市化，婚姻状况和职业。除结肠癌外，没有解剖学癌症部位与任何氯剂量暴露类别显著相关。对于结肠癌，高、中、低剂量氯化的优势比分别为1.51 [95%置信区间（CI）= 1.06-2.14]、1.53 [95% CI =1.08-2.00]和1.53 [95% CI-1.11-2.11]（P小于或等于0.02）。对于暴露于受农村径流影响的水源的结肠癌病例和对照，观察到20年前高、中、低氯剂量的优势比分别为3.30（95%CI =1.45-7.47）、3.60（95%CI =1.57-8.26）和2.74（95%CI =1.10-6.88）（P小于或等于0.025）。
The association between gastrointestinal, urinary tract, brain, lung, and breast cancer mortality and drinking water trihalomethane exposure, as estimated by average daily chlorine dosage of water source 20 years past, was investigated for Wisconsin white females by use of a death certificate-based case-control study design. A total of 8,029 cancer deaths and 8,029 controls (noncancer deaths) matched on county of residence, year of death, and age were taken from mortality records of 28 counties for the years 1972-77. Data on characteristics and treatment of municipal water supplied to the residences of cases and controls were obtained from questionnaires sent to the water superintendents of the 202 waterworks associated with the sample. By the use of logistic regression analysis, odds ratios for site-specific cancer death associated with high, medium, and low chlorine-dosed water as compared to unchlorinated water exposure were determined; the control variables were urbanicity, marital status, and occupation. With the exception of cancer of the colon, no anatomic cancer site was significantly associated with any chlorine dose exposure category. For colon cancer, odds ratios of 1.51 [95% confidence interval (Cl) = 1.06-2.14], 1.53 (95% Cl=1.08-2.00, and 1.53 (95% Cl-1.11-2.11) were obtained for high-, medium-, and low-dose chlorination, respectively (P less than or equal to 0.02). For colon cancer cases and controls exposed to water sources affected by rural runoff, odds ratios of 3.30 (95% Cl=1.45-7.47), 3.60 (95% Cl=1.57-8.26), and 2.74 (95% Cl=1.10-6.88) were observed for high, medium, and low chlorine dosages 20 years past (P less than or equal to 0.025).