Identification of a dietary pattern characterized by high-fat food choices associated with increased risk of breast cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
Identification of a dietary pattern characterized by high-fat food choices associated with increased risk of breast cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
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DOI：
10.1017/s0007114508966149
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发表时间：
2008-11-01
影响因子：
3.6
通讯作者：
Boeing, Heiner
中科院分区：
文献类型：
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作者：
Schulz, Mandy;Hoffmann, Kurt;Boeing, Heiner
到目前为止，进行的流行病学研究主要使用单一营养素方法，这可能不足以检测饮食与癌症的关系。这项研究的目的是通过降低等级回归的方法来检查基于脂肪酸摄入量的解释变化的食物模式与乳腺癌风险的关联。研究参与者是欧洲癌症和营养前瞻性调查(EPIC)-波茨坦无癌症研究的女性受试者(IT 15 35 1)，基线为零，并对完整的饮食和结果信息进行了平均6.0年的跟踪调查。在这些人中。共查出137例浸润性乳腺癌病例。我们确定了一种以低面包消费为特征的饮食模式。还有果汁。以及大量食用加工肉类、鱼、黄油和其他动物脂肪。人造黄油解释了脂肪酸摄入量(SFA)总变异的42%。MUFA、n-3 PUFA、n-6 PUFA)。所有四种脂肪酸的摄入量与模式得分呈正相关。对协变量进行调整后，坚持这种食物模式与乳腺癌风险的两倍相关(风险比2-00，95%可信区间1.30，3.09)，与模式得分的极端三分之比较。没有证据表明绝经状态对效果有影响。超重状况和激素替代疗法的使用。分别进行了分析。总而言之，以高脂肪食物选择为特征的饮食模式是SIT，与乳腺癌风险的增加显著相关。考虑到食物模式中所有脂肪酸的含量都很高。我们发现了总膳食脂肪而不是特定脂肪酸与乳腺癌风险相关的证据。
Epidemiological studies conducted thus far have mainly used a sin-le-nutrient approach which may not be sufficient in detecting diet-cancer relationships. The aim Of the Study was to examine the association of a food pattern based on explained variations in fatty acid intake by means of reduced rank regression with breast cancer risk. Study participants were female subjects (it 15 35 1) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study free of cancer at baseline and with complete dietary and Outcome information followed for an average of 6.0 years. Among those. 137 incident cases of invasive breast cancer were identified. We identified a food pattern characterized by low consumption of bread. and fruit juices. and high consumption of processed meat, fish, butter and other animal fats. and margarine explaining >42% of total variation in fatty acid intake (SFA. MUFA, n-3 PUFA, n-6 PUFA). Intake of all four fatty acid fractions was positively associated with the pattern score. Adherence to this food pattern adjusted for covariates was associated with a two-fold risk (hazard ratio 2-00 95% CI 1.30, 3.09) of breast cancer comparing extreme tertiles of the pattern score. There was no evidence of effect modification by menopausal Status. overweight status and use of hormone replacement therapy. respectively. In conclusion, a food pattern characterized by high-fat food choices was sit,significantly associated with increased risk of breast cancer. Given that the food pattern was high in all fatty acid fractions. we found evidence for total dietary fat rather than for specific fatty acids to be associated with breast cancer risk.