Fruit, vegetables, and antioxidants in childhood and risk of adult cancer: the Boyd Orr cohort
Fruit, vegetables, and antioxidants in childhood and risk of adult cancer: the Boyd Orr cohort
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DOI：
10.1136/jech.57.3.218
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发表时间：
2003-03-01
影响因子：
6.3
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Maynard, M;Gunnell, D;Smith, GD
研究目的：在一个随访超过60年的队列中，研究儿童期测量的食物和营养摄入与成人癌症之间的关系。设计和设置：该研究基于Boyd Orr队列。1937 ~ 1939年，在英格兰和苏格兰的16个农村和城市地区进行了一项家庭饮食和健康研究，根据7天的家庭食物清单评估了水果和蔬菜、能量、维生素C和E、胡萝卜素和视黄醇的摄入量。参与者：4999名男性和女性，大部分来自工人阶级背景，他们是参加战前调查的家庭的儿童。分析的基础上追踪的3878例受试者的饮食和社会环境的完整数据。主要结果：在随访期间有483例恶性肿瘤事件。儿童期水果摄入量的增加与癌症发病风险的降低有关。在完全调整的逻辑回归模型中，随着水果消费量四分位数的增加，优势比（95%置信区间）分别为1.0（参考）、0.66（0.48至0.90）、0.70（0.51至0.97）、0.62（0.43至0.90）;线性趋势的p值=0.02。癌症死亡率的相关性较弱。有没有明确的模式之间的关联其他饮食因素和总cancer risk.Conclusions：儿童水果消费可能有长期的保护作用，在成年人的癌症风险。进一步的前瞻性研究，与个人的饮食措施，需要进一步阐明这些关系。
Study objective: To examine associations between food and nutrient intake, measured in childhood, and adult cancer in a cohort with over 60 years follow up.Design and setting: The study is based on the Boyd Orr cohort. Intake of fruit and vegetables, energy, vitamins C and E, carotene, and retinol was assessed from seven day household food inventories carried out during a study of family diet and health in 16 rural and urban areas of England and Scotland in 1937-39.Participants: 4999 men and women, from largely working class backgrounds, who had been children in the households participating in the pre-war survey. Analyses are based on 3878 traced subjects with full data on diet and social circumstances.Main results: Over the follow up period there were 483 incident malignant neoplasms. Increased childhood fruit intake was associated with reduced risk of incident cancer. In fully adjusted logistic regression models, odds ratios (95% confidence intervals) with increasing quartiles of fruit consumption were 1.0 (reference), 0.66 (0.48 to 0.90), 0.70 (0.51 to 0.97), 0.62 (0.43 to 0.90); p value for linear trend=0.02. The association was weaker for cancer mortality. There was no clear pattern of association between the other dietary factors and total cancer risk.Conclusions: Childhood fruit consumption may have a long term protective effect on cancer risk in adults. Further prospective studies, with individual measures of diet are required to further elucidate these relations.