Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
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DOI：
10.1038/s41577-020-0331-4
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发表时间：
2020-05-06
影响因子：
100.3
通讯作者：
Martin, Jerome C.
中科院分区：
文献类型：
--
作者：
Merad, Miriam;Martin, Jerome C.
由SARS-CoV-2感染引起的COVID-19大流行已导致全球超过20万人死亡。几项研究现已证实，SARS-CoV-2诱导的高度炎症反应是感染患者疾病严重程度和死亡的主要原因。巨噬细胞是一群先天免疫细胞，它们通过产生炎症分子来感知和应对微生物的威胁，这些炎症分子可以消除病原体并促进组织修复。然而，巨噬细胞反应失调可能会损害宿主，如严重感染诱导的巨噬细胞活化综合征，包括相关病毒SARS-CoV感染。在这里，我们描述了SARS-CoV-2感染期间巨噬细胞的潜在病理作用，并讨论了正在进行的和前瞻性的治疗策略，以调节COVID-19患者的巨噬细胞活化。Merad和Martin的这篇进展文章探讨了我们目前对严重COVID-19患者过度炎症反应的理解。作者重点关注单核细胞和巨噬细胞的新兴病理作用，并讨论了目前在临床上靶向的炎症途径。
The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activation syndrome induced by severe infections, including in infections with the related virus SARS-CoV. Here we describe the potentially pathological roles of macrophages during SARS-CoV-2 infection and discuss ongoing and prospective therapeutic strategies to modulate macrophage activation in patients with COVID-19.This Progress article from Merad and Martin examines our current understanding of the excessive inflammatory responses seen in patients with severe COVID-19. The authors focus on the emerging pathological roles of monocytes and macrophages and discuss the inflammatory pathways that are currently being targeted in the clinic.