Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564
Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564
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Koshidacins A 和 B，来自冲绳真菌 Pochonia boninensis FKR-0564 的抗疟原虫环状四肽
DOI：
10.1021/acs.jnatprod.2c00719
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发表时间：
2022
期刊：
影响因子：
5.1
通讯作者：
Toshiaki Teru
中科院分区：
文献类型：
--
作者：
Yoshihiro Watanabe;Kodai Hachiya;Akari Ikeda;Kenichi Nonaka;Mayuka Higo;Reiko Muramatsu;Chikako Noguchi;Masako Honsho;Yukihiro Asami;Yuki Inahashi;Tomoyasu Hirose;Hidehito Matsui;Toshiaki Sunazuka;Hideaki Hanaki;Takahiro Ishii;Toshiaki Teru
从冲绳真菌 Pochonia boninensisFKR-0564 的培养液中发现了两种新的抗疟原虫肽，名为 koshidacins A (1) 和 B (2)。它们的结构，包括绝对构型，是通过光谱方法和化学衍生化的结合来阐明的。两种化合物均对恶性疟原虫菌株表现出中等的体外抗疟原虫活性，IC50 值范围为 17.1 至 0.83 μM。此外，当以30mg/kg/天的剂量腹膜内施用4天时，化合物2在体内抑制了41%的疟疾寄生虫。
Two new antiplasmodial peptides, named koshidacins A (1) and B (2), were discovered from the culture broth of the Okinawan fungusPochonia boninensisFKR-0564. Their structures, including absolute configurations, were elucidated by a combination of spectroscopic methods and chemical derivatization. Both compounds showed moderatein vitroantiplasmodial activity againstPlasmodium falciparumstrains, with IC50values ranging from 17.1 to 0.83 μM. In addition, compound2suppressed 41% of malaria parasitesin vivowhen administered intraperitoneally at a dose of 30 mg/kg/day for 4 days.