The impact of consanguinity on neonatal and infant health
The impact of consanguinity on neonatal and infant health
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DOI：
10.1016/j.earlhumdev.2010.08.003
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发表时间：
2010-11-01
影响因子：
2.5
通讯作者：
Black, M. L.
中科院分区：
文献类型：
--
作者：
Bittles, A. H.;Black, M. L.
血亲之间的婚姻在世界上许多地方都很流行，有超过10亿人生活在20- 50%以上的婚姻是在第二堂兄弟姐妹或近亲之间签订的国家。然而，血缘关系是一个有争议的话题，部分原因是公众的误解，加上过去对不利健康结果的估计往往被夸大。虽然一些近亲夫妇有很高的风险怀上一个有遗传疾病的孩子，但他们只是少数。因此，一项多人群荟萃分析表明，近亲后代的婴儿死亡率高出1.1%，即使是这个数字也可能由于对非遗传变量控制不足而受到影响。评估和讨论了近亲婚姻的好处和缺点，特别考虑到西方国家移民社区的健康，其中第一堂兄弟婚姻仍然是优先考虑的。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Marriage between biological relatives is widely popular in many parts of the world, with over 1000 million people living in countries where 20-50+% of unions are contracted between couples related as second cousins or closer. Consanguinity is, however, a controversial topic, in part due to public misunderstanding, complicated by often exaggerated past estimates of the adverse health outcomes. While some consanguineous couples are at high risk of conceiving a child with a genetic disorder, they are a small minority. Thus a multi-population meta-analysis has indicated an excess infant death rate of 1.1% in the progeny of first cousins, and even this figure may be compromised by inadequate control for non-genetic variables. The benefits as well as the disadvantages of consanguineous marriage are assessed and discussed, with specific consideration given to the health of migrant communities in Western countries, among whom first cousin marriage remains preferential. (C) 2010 Elsevier Ireland Ltd. All rights reserved.