SYNTHESIS AND CELL BEHAVIOR OF APATITIC BARIUM RARE EARTH OXIDE SILICATES
SYNTHESIS AND CELL BEHAVIOR OF APATITIC BARIUM RARE EARTH OXIDE SILICATES
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磷灰石稀土氧化硅酸钡的合成和细胞行为
DOI：
10.1142/9789814291064_0052
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
K. Yamashita
中科院分区：
文献类型：
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作者：
T. Kizuki;M. Ohgaki;K. Hashimoto;Y. Toda;S. Udagawa;K. Yamashita
研究了含有稀土元素的硅酸盐磷灰石生物材料的合成及其在生物医学用途中的应用。使用 BaCO3、SiO2、La2O3 在空气中于 1400°C 下固相反应 2h 合成了氧化硅酸钡镧 (Ba2+xLa8−x(SiO4)6O2−x/2)。由此获得的粉末(Ba 2 La 8 (SiO 4 ) 6 O 2 )通过XRD鉴定为氧化硅酸钡镧(磷灰石型)的单相。经IR证实存在氧磷灰石，通过IR显示羟基。通过ESCA、EDX分析磷灰石的成分。 Ba4La6(SiO4)6O 被烧结。在1400℃空气中2h的条件下获得96%的相对密度。采用与氧化硅酸钡镧相同的条件合成稀土氧化硅酸钡(Ba2+xLn8-x(SiO4)6O2−x/2Ln=Pr、Nd、Sm、Eu、Gd)。将样品制成颗粒，用于成骨细胞样细胞（MC3T3-E1）和成纤维细胞（L929）的生物相容性实验。通过SEM观察氧化硅酸钡镧的电池行为。观察粘附在样品表面的细胞数量。这些结果证实了稀土氧化物硅酸钡的生物相容性。
Synthesis and applicability of silicate apatite containing rare earth elements as biomaterial were studied for biomedical use. Barium lanthanum oxide silicates (Ba2+xLa8−x(SiO4)6O2−x/2) were synthesized by solid state reaction using BaCO3, SiO2, La2O3at 1400°C in air for 2h. The powder (Ba2La8(SiO4)6O2) thus obtained was identified single phase of barium lanthanum oxide silicate (apatite type) by XRD. There were oxyapatite, as was confirmed by IR revealing hydroxyl by IR. Compositions of the apatite were analyzed by ESCA, EDX. Ba4La6(SiO4)6O was sintered. The relative density of 96% was obtained under condition at 1400°C in air for 2h. Barium rare earth oxide silicates (Ba2+xLn8-x(SiO4)6O2−x/2Ln= Pr, Nd, Sm, Eu, Gd) were synthesized by the same condition as that of barium lanthanum oxide silicate. The samples were formed to pellets for the biocompatible experiments with osteoblast-like cell (MC3T3-El) and fibroblast cell (L929). Cell behaviors on barium lanthanum oxide silicates were observed by SEM. The number of cells which adhered on the samples surface were observed. These results comfirmed biocompatibility of barium rare earth oxide silicates.