INTERNATIONAL CLASSIFICATION OF HEALTH PROBLEMS IN PRIMARY CARE
INTERNATIONAL CLASSIFICATION OF HEALTH PROBLEMS IN PRIMARY CARE
复制标题
初级保健中健康问题的国际分类
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
M. Smith
中科院分区：
文献类型：
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作者：
M. Smith
手术后单一药剂辅助（预防性）化疗仅提供最小鼓励且常常是矛盾的结果。“现在，更积极的化疗正在被定义，并且对辅助化疗的要求有了更深入的了解，适当进行的试验评估了这种方法在明显治愈的手术切除后的高危患者中的作用。在澳大利亚也正在进行一项胃癌辅助化疗的多机构试验，将5 FU、阿霉素和BCNU联合治疗与手术后不进行后续治疗进行比较。如果这种组合在晚期环境中的潜力在疾病的早期阶段仍然存在，那么在初始确定性治疗后复发的患者比例应该显著下降。然而，重要的是，这些试验必须适当和谨慎地进行，因为这些组合具有潜在的毒性，并且不能保证成功。如果这些研究证实了化疗的前景，那么胃癌患者的未来将是相当乐观的。
single-agent adjuvant (prophylactic) chemotherapy after surgery have provided only minimal encouragement and often conflicting results." Now that more active chemotherapy is being defined and a greater understanding ofthe requirements of adjuvant chemotherapy is available, properly conducted trials evaluating this approach in patients at high risk after apparently curative surgical resection are clearly indicated. A multi-institutional trial of adjuvant chemotherapy for gastric cancer is also being undertaken in Australia, where the combination of 5FU, doxorubicin and BCNU is compared with no subsequent 'therapy after surgery. If the potential for this combination in the advanced setting holds true in the earlier stages of disease, then the proportion of patients relapsing after initial definitive therapy should significantly decline. However, it is important that these trials be conducted properly and with caution, as these combinations are potentially toxic and success is by no means guaranteed. If these studies confirm the promise of chemotherapy, then the future for patients with gastric cancer will be one of considerably greater optimism.