CREB at the Crossroads of Activity-Dependent Regulation of Nervous System Development and Function
CREB at the Crossroads of Activity-Dependent Regulation of Nervous System Development and Function
复制标题
DOI：
10.1007/978-3-319-62817-2_2
复制
发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Borodinsky, Laura N.
中科院分区：
文献类型：
--
作者：
Belgacem, Yesser H.;Borodinsky, Laura N.
中枢神经系统是一个高度可塑的细胞网络，在整个生命过程中不断调整其功能以适应环境刺激。转录依赖性机制改变神经元特性以响应调节许多发育功能（如细胞存活和分化）和生理功能（如学习、记忆和昼夜节律）的外部刺激。环磷酸腺苷（cAMP）反应元件结合蛋白（CREB）的发现和克隆，使神经可塑性的分子机制研究向前迈进了一大步。CREB最初是在学习和记忆研究中发现的，作为靶基因表达的活性依赖性变化的关键介导剂，这反过来又会对神经元的结构和功能产生持久的修饰。在本章中，我们综述了CREB及其辅因子的神经活性依赖性募集的分子和信号机制。我们讨论了信号通路之间的串扰，印记不同的时空模式的CREB激活允许整合各种各样的刺激。
The central nervous system is a highly plastic network of cells that constantly adjusts its functions to environmental stimuli throughout life. Transcription-dependent mechanisms modify neuronal properties to respond to external stimuli regulating numerous developmental functions, such as cell survival and differentiation, and physiological functions such as learning, memory, and circadian rhythmicity. The discovery and cloning of the cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB) constituted a big step toward deciphering the molecular mechanisms underlying neuronal plasticity. CREB was first discovered in learning and memory studies as a crucial mediator of activity-dependent changes in target gene expression that in turn impose long-lasting modifications of the structure and function of neurons. In this chapter, we review the molecular and signaling mechanisms of neural activity-dependent recruitment of CREB and its cofactors. We discuss the crosstalk between signaling pathways that imprints diverse spatiotemporal patterns of CREB activation allowing for the integration of a wide variety of stimuli.