Distribution and morphological features of microglia in the developing cerebral cortex of gyrencephalic mammals
Distribution and morphological features of microglia in the developing cerebral cortex of gyrencephalic mammals
复制标题
环脑哺乳动物大脑皮层发育中小胶质细胞的分布和形态特征
DOI：
10.1007/s11064-018-2520-0
复制
发表时间：
2018
影响因子：
4.4
通讯作者：
Shinmyo Y. and Kawasaki H.
中科院分区：
文献类型：
--
作者：
Mizuguchi K.;Horiike T.;Matsumoto N.;Ichikawa Y.;Shinmyo Y. and Kawasaki H.
小胶质细胞由于其在成熟脑和发育脑中的重要作用而受到广泛关注。尽管小胶质细胞在小鼠大脑皮层发育中的重要作用已被发现，但其在脑回型高等哺乳动物大脑皮层发育中的分布和作用仍不清楚。在这里，我们研究了小胶质细胞的分布和形态学的脑回型食肉雪貂大脑皮层的发展。我们发现，大量的小胶质细胞聚集在生殖区（GZ），特别是在外部脑室下区（OSVZ），这是一个在高等哺乳动物中发现的GZ。此外，我们发现，小胶质细胞延伸其进程切向沿着内纤维层（IFL）样纤维在发育雪貂皮层。OSVZ和IFL是高等哺乳动物大脑皮层的显著特征。我们的研究结果表明，小胶质细胞可能在高等哺乳动物大脑皮层发育中的OSVZ和IFL中发挥重要作用。
Microglia have been attracting much attention because of their fundamental importance in both the mature brain and the developing brain. Though important roles of microglia in the developing cerebral cortex of mice have been uncovered, their distribution and roles in the developing cerebral cortex in gyrencephalic higher mammals have remained elusive. Here we examined the distribution and morphology of microglia in the developing cerebral cortex of gyrencephalic carnivore ferrets. We found that a number of microglia were accumulated in the germinal zones (GZs), especially in the outer subventricular zone (OSVZ), which is a GZ found in higher mammals. Furthermore, we uncovered that microglia extended their processes tangentially along inner fiber layer (IFL)-like fibers in the developing ferret cortex. The OSVZ and the IFL are the prominent features of the cerebral cortex of higher mammals. Our findings indicate that microglia may play important roles in the OSVZ and the IFL in the developing cerebral cortex of higher mammals.