EFFECTS OF HUMAN INTRAVENOUS IMMUNE GLOBULIN ON DIARRHEA CAUSED BY SHIGA-LIKE TOXIN-I AND SHIGA-LIKE TOXIN-II IN INFANT RABBITS
EFFECTS OF HUMAN INTRAVENOUS IMMUNE GLOBULIN ON DIARRHEA CAUSED BY SHIGA-LIKE TOXIN-I AND SHIGA-LIKE TOXIN-II IN INFANT RABBITS
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DOI：
10.1111/j.1348-0421.1992.tb02111.x
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发表时间：
1992-01-01
影响因子：
2.6
通讯作者：
BURD, EM
中科院分区：
文献类型：
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作者：
HAVENS, PL;DUNNE, WM;BURD, EM
由大肠杆菌产生的滋贺毒素及其相关的志贺样毒素（Shiga-like toxins，SHG）可引起出血性结肠炎和溶血性尿毒综合征（hemolytic uremic syndrome，HUS）。人静脉注射免疫球蛋白（HIVIg）在体外阻断某些SLT的细胞毒性。为了检查HIVIg修饰由志贺样毒素I或志贺样毒素II（SLT-I或SLT-II）引起的疾病的能力，我们用来自大肠杆菌O 157：H7的含有SLT-free上清液腹膜内注射3日龄的兔子。用皮下HIVIg处理一部分家兔。所有给予10（4）CD 50的家兔均出现严重腹泻，5只死亡。当HIVIg 500 mg/kg与抗病毒药物联合给药时，18只家兔中仅有6只（33.3%）出现腹泻（P
Shiga toxin and the related Shiga-like toxins (SLT), produced by Escherichia coli, can cause hemorrhagic colitis and hemolytic uremic syndrome (HUS). Human intravenous immune globulin (HIVIg) blocks the cytotoxicity of some SLTs in vitro. To examine the ability of HIVIg to modify disease caused by Shiga-like toxin I or Shiga-like toxin II (SLT-I or SLT-II), we injected 3-day-old rabbits intraperitoneally with SLT-containing cell-free supernatants from Escherichia coli O157: H7. A subset of rabbits was treated with subcutaneous HIVIg. All rabbits given 10(4) CD50 of SLT-1 developed severe diarrhea, and 5 died. When HIVIg 500 mg/kg was given in addition to SLT-1, only 6 of 18 rabbits (33.3%) developed diarrhea (P