Room-temperature copper-catalyzed α-arylation of malonates
Room-temperature copper-catalyzed α-arylation of malonates
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DOI：
10.1021/ol701473p
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发表时间：
2007-08-16
期刊：
影响因子：
5.2
通讯作者：
Kwong, Fuk Yee
中科院分区：
文献类型：
--
作者：
Yip, Sau Fan;Cheung, Hong Yee;Kwong, Fuk Yee
报道了一种靶向α-芳基丙二酸酯的有效方法。在催化量的2-吡啶甲酸和CuI的存在下，芳基碘与丙二酸二乙酯的偶联即使在室温下也顺利进行。高水平的官能团相容性和异常温和的反应条件为获得各种芳基化丙二酸酯提供了有吸引力的方案。
An effective method in targeting alpha-aryl malonates is reported. In the presence of a catalytic amount of 2-picolinic acid and CuI, the coupling of aryl iodides with diethyl malonate proceeds smoothly even at room temperature. The high levels of functional group compatibility and exceptionally mild reaction conditions offer this an attractive protocol in accessing a variety of arylated malonates.