Mechanisms and consequences of activation of protein kinase B/Akt
Mechanisms and consequences of activation of protein kinase B/Akt
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DOI：
10.1016/s0955-0674(98)80149-x
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发表时间：
1998-04-01
影响因子：
7.5
通讯作者：
Downward, J
中科院分区：
文献类型：
--
作者：
Downward, J
蛋白激酶B（PKB）/Akt是一种生长因子调节的丝氨酸/苏氨酸激酶，含有一个普列克底物蛋白同源结构域。磷酸肌醇3-OH激酶产物与pleckstrin同源结构域的结合导致PKB/Akt易位至质膜，在那里它被上游激酶（包括磷酸肌醇依赖性激酶1（PDK 1））磷酸化激活。激活的PKB/Akt提供了一种保护细胞免受各种应激诱导的凋亡的存活信号，并且还介导了胰岛素的许多代谢作用。(C)Current Biology Ltd ISSN 0955-0674。
Protein ki nase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin. (C) Current Biology Ltd ISSN 0955-0674.