Lymphatic Function and Dysfunction in the Context of Sex Differences.
Lymphatic Function and Dysfunction in the Context of Sex Differences.
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DOI：
10.1021/acsptsci.9b00051
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发表时间：
2019-09
影响因子：
6
通讯作者：
Claire E. Trincot;K. Caron
中科院分区：
文献类型：
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作者：
Claire E. Trincot;K. Caron
内皮细胞是血管系统的构建块，并且在染色体和激素性别方面表现出充分表征的性二态表型，赋予男性和女性血管系统和心血管疾病之间的先天遗传和生理差异。然而，即使女性主要受淋巴管功能紊乱的影响，我们缺乏一个全面的了解性和性激素对淋巴管的生长，功能和功能障碍的影响。在这里，我们试图全面评估目前的理解性别作为一个生物变量影响淋巴生物学。我们首先集中在阐明淋巴功能和发展的性别之间的先天和根本的差异。接下来，我们深入研究淋巴疾病，并探索女性人群中偏见流行的潜在基础。最后，我们更广泛地纳入淋巴系统在性别偏见疾病，如癌症，心血管疾病，生殖系统疾病和自身免疫性疾病中的作用，以探讨性别差异是否以及如何影响淋巴功能在这些病理的背景下。
Endothelial cells are the building blocks of the blood vascular system and exhibit well-characterized sexually dimorphic phenotypes with regard to chromosomal and hormonal sex, imparting innate genetic and physiological differences between male and female vascular systems and cardiovascular disease. However, even though females are predominantly affected by disorders of lymphatic vascular function, we lack a comprehensive understanding of the effects of sex and sex hormones on lymphatic growth, function, and dysfunction. Here, we attempt to comprehensively evaluate the current understanding of sex as a biological variable influencing lymphatic biology. We first focus on elucidating innate and fundamental differences between the sexes in lymphatic function and development. Next, we delve into lymphatic disease and explore the potential underpinnings toward bias prevalence in the female population. Lastly, we incorporate more broadly the role of the lymphatic system in sex-biased diseases such as cancer, cardiovascular disease, reproductive disorders, and autoimmune diseases to explore whether and how sex differences may influence lymphatic function in the context of these pathologies.