Use of unphased multilocus genotype data in indirect association studies
Use of unphased multilocus genotype data in indirect association studies
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DOI：
10.1002/gepi.20032
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发表时间：
2004-12-01
影响因子：
2.1
通讯作者：
Cooper, J
中科院分区：
文献类型：
--
作者：
Clayton, D;Chapman, J;Cooper, J
通常认为，考虑标记单倍型有助于通过与疾病易感性基因连锁不平衡的标记多态性检测疾病易感性基因。然而，捕获的标记单倍型信息需要分辨率的配子相，这通常必须推断统计最近，我们质疑的标记单倍型信息的价值，并建议，某些分析的多变量标记数据，而不是基于单倍型明确和不需要分辨率的配子相，往往是更强大的分析基于单倍型。在这里，我们回顾这项工作，并更仔细地评估我们的结论可能适用的情况下，我们还将这些分析与单倍型分析的替代方法，即那些基于单倍型相似性和分支系统学的启发。Genet.流行病学(C)2004 Wiley-Liss，Inc.
It is usually assumed that detection of a disease susceptability gene via marker polymorphisms in linkage disequilibrium with it is facilitated by consideration of marker haplotypes. However, capture of the marker haplotype information requires resolution of gametic phase, and this must usually be inferred statistically Recently, we questioned the value of the marker haplotype information, and suggested that certain analyses of multivariate marker data, not based on haplotypes explicitly and not requiring resolution of gametic phase, are often more powerful than analyses based on haplotypes. Here, we review this work and assess more carefully the situations in which our conclusions might apply We also relate these analyses to alternative approaches to haplotype analysis, namely those based on haplotype similarity and those inspired by cladistics. Genet. Epidemiol. (C) 2004 Wiley-Liss, Inc.