The role of prefrontal cortex in verbal episodic memory: rTMS evidence
The role of prefrontal cortex in verbal episodic memory: rTMS evidence
复制标题
DOI：
10.1162/089892903322370771
复制
发表时间：
2003-08-15
影响因子：
3.2
通讯作者：
Miniussi, C
中科院分区：
文献类型：
--
作者：
Sandrini, M;Cappa, SF;Miniussi, C
长期的情景记忆处理过程应该不对称地涉及前额叶皮层。在这里，我们调查的作用，背外侧前额叶皮层（DLPFC）在编码和检索的语义相关或不相关的词对。受试者被要求执行一项任务，包括两个部分：一个研究阶段（编码），在其中提出的字对，和一个测试阶段（检索），在此期间，以前提出的刺激已被确认在其他刺激。重复经颅磁刺激（rTMS）对情景记忆有显著影响，这与我们以前使用图片的研究结果一致。当rTMS被应用于左或右DLPFC在编码过程中，和右DLPFC在检索中，但只对不相关的词对的性能显着中断。这些结果表明，要记住的材料的性质与编码-提取DLPFC的不对称性相互作用;此外，DLPFC的关键作用是显而易见的，只有新的刺激。
Long-term, episodic memory processing is supposed to involve the prefrontal cortex asymmetrically. Here we investigate the role of the dorsolateral prefrontal cortex (DLPFC) in encoding and retrieval of semantically related or unrelated word pairs. Subjects were required to perform a task consisting of two parts: a study phase (encoding), in which word pairs were presented, and a test phase (retrieval), during which stimuli previously presented had to be recognized among other stimuli. Consistently with Our previous findings using pictures, repetitive transcranial magnetic stimulation (rTMS) had a significant impact on episodic memory. The performance was significantly disrupted when rTMS was applied to the left or right DLPFC during encoding, and to the right DLPFC in retrieval, but only for unrelated word pairs. These results indicate that the nature of the material to be remembered interacts with the encoding-retrieval DLPFC asymmetry; moreover, the crucial role of DLPFC is evident only for novel stimuli.