Influence of kinins and angiotensin II on the regulation of papillary blood flow.
Influence of kinins and angiotensin II on the regulation of papillary blood flow.
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激肽和血管紧张素II对乳头血流调节的影响。
DOI：
10.1152/ajprenal.1988.255.4.f690
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Carretero,OA
中科院分区：
文献类型：
--
作者：
Roman,RJ;Kaldunski,ML;Scicli,AG;Carretero,OA
研究了激肽和血管紧张素II对大鼠肾皮质和乳头血流及钠和水排泄的调节作用。采用激光多普勒血流仪测量皮层浅层和乳头状血流。依那普利（60微克/千克）和磷酰胺（5.5微克/千克-1）后乳头血流量增加50%。min-1)与0.3 M碳酸氢钠溶液一起给予抑制激肽降解，增强尿钾激肽活性。输注激肽拮抗剂d - arg - hy - thi - d - ph -bradykinin（5微克/分钟），使乳头血流量恢复到控制水平。在服用激酶抑制剂和碳酸氢钠后，尿流量和钠排泄增加，而肾小球滤过率（GFR）和外皮质血流量没有改变。激肽拮抗剂没有改变大鼠接受激肽酶抑制剂和碳酸氢盐的钠和水排泄。单独使用激肽拮抗剂可使乳头状血流量降低20%，而不影响外皮层血流量或GFR。大鼠服用激肽拮抗剂后，尿流量减少，尿渗透压升高，但钠排泄保持不变。为了评估血管紧张素II在控制乳头血流中的作用，我们通过输注拮抗剂阻断激肽受体，并研究依那普利特和萨拉拉西的作用。大鼠接受激肽拮抗剂阻断血管紧张素II系统后，乳头状血流量增加。这些结果表明，钾likrein-kinin和肾素-血管紧张素系统参与了乳头状血流的调节。
The influence of kinins and angiotensin II on the regulation of renal cortical and papillary blood flow and sodium and water excretion was examined in rats. Superficial cortical and papillary blood flows were measured using a laser-Doppler flowmeter. Papillary blood flow increased 50% after enalaprilat (60 micrograms/kg) and phosphoramidon (5.5 micrograms.kg-1.min-1) were given along with 0.3 M sodium bicarbonate solution to inhibit degradation of kinins and enhance urinary kallikrein activity. Infusion of a kinin antagonist, D-Arg-Hyp-Thi-D-Phe-bradykinin (5 micrograms/min), returned papillary blood flow to control levels. Urine flow and sodium excretion increased after the administration of the kininase inhibitors and sodium bicarbonate, while glomerular filtration rate (GFR) and outer cortical blood flow were unaltered. The kinin antagonist did not alter sodium and water excretion in rats receiving the kininase inhibitors and bicarbonate. Administration of the kinin antagonist alone lowered papillary blood flow by 20%, without affecting outer cortical blood flow or GFR. Urine flow decreased and urine osmolality increased after the rats received the kinin antagonist, but sodium excretion remained unaltered. To assess the role of angiotensin II in the control of papillary blood flow, kinin receptors were blocked by infusion of an antagonist, and the effects of enalaprilat and saralasin were studied. Papillary blood flow increased after blockade of the angiotensin II system in rats receiving the kinin antagonist. These results indicate that the kallikrein-kinin and renin-angiotensin systems participate in the regulation of papillary blood flow.