Determinants of primate neurogenesis and the deployment of top-down generative networks in the cortical hierarchy
Determinants of primate neurogenesis and the deployment of top-down generative networks in the cortical hierarchy
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DOI：
10.1016/j.conb.2020.09.012
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发表时间：
2020-10
影响因子：
5.7
通讯作者：
H. Kennedy;F. Wianny;C. Dehay
中科院分区：
文献类型：
--
作者：
H. Kennedy;F. Wianny;C. Dehay
我不能创造什么，我不明白-理查德·费曼1978因为灵长类皮层发育表现出许多特定的特征，老鼠是人类皮层发育的一个不完美的模型。颗粒上神经元的扩张是灵长类大脑皮层的一个进化特征。颗粒上神经元产量的增加得到灵长类大脑皮层生发区创新的支持：外室下区，它沿着颗粒上神经元构成灵长类大脑特异性基因进化的特权靶点。由此产生的细胞类型多样性的人类颗粒上神经元链接的细胞和分子的进化变化的祖细胞与灵长类动物皮层中出现的独特的建筑特征。我们建议，这些变化是需要的灵长类动物皮层层次结构的扩展部署自上而下的生成网络与人类精神疾病的神经生物学的潜在重要后果。
What I cannot create I do not understand— Richard Feynman 1978Because primate cortical development exhibits numerous specific features, the mouse is an imperfect model for human cortical development. Expansion of supragranular neurons is an evolutionary feature characterizing the primate cortex. Increased production of supragranular neurons is supported by a germinal zone innovation of the primate cortex: the Outer SubVentricular Zone, which along with supragranular neurons constitute privileged targets of primate brain-specific gene evolution. The resulting cell-type diversity of human supragranular neurons link cell and molecular evolutionary changes in progenitors with the emergence of distinctive architectural features in the primate cortex. We propose that these changes are required for the expansion of the primate cortical hierarchy deploying top-down generative networks with potentially important consequences for the neurobiology of human psychiatric disorders.