Modelling and simulation of acrylic bone cement injection and curing within the framework of vertebroplasty
Modelling and simulation of acrylic bone cement injection and curing within the framework of vertebroplasty
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DOI：
10.1002/zamm.201400064
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发表时间：
2015-12-01
影响因子：
2.3
通讯作者：
Kober, Cornelia
中科院分区：
文献类型：
--
作者：
Landgraf, Ralf;Ihlemann, Joern;Kober, Cornelia
椎体成形术是一种治疗椎体压缩性骨折的微创手术技术。在治疗过程中，液体骨水泥被注射到受影响的椎体中，并在其中固化成固体。为了研究注射骨水泥的治疗和影响，开发了一个集成的建模和仿真框架。该框架包括(i)基于人体松质骨的微ct图像生成微结构计算机模型，（ii）骨水泥注入小梁结构的计算流体动力学（CFD）模拟，以及（iii）随后骨水泥固化的非线性有限元（FE）模拟。为两个模拟阶段提供了丙烯酸骨水泥材料行为的详细描述。选择一个非线性过程相关的粘度函数来表示骨水泥在注射过程中的行为。骨水泥从高粘性流体到固体的相变由具有固化相关特性的非线性粘弹性材料模型来描述。考虑到丙烯酸骨水泥独特的温度依赖性，两种材料模型都以热-机械耦合的方式制定。此外，利用热-机械耦合求解器进行了相应的微观结构CFD和fe模拟。将所提出的建模和仿真框架应用于人类松质骨样本，证明了所提出方法的能力。(C) 2015 WILEY-VCH Verlag GmbH & Co., KGaA, Weinheim
The minimal invasive procedure of vertebroplasty is a surgical technique to treat compression fractures of vertebral bodies. During the treatment, liquid bone cement gets injected into the affected vertebral body and therein cures to a solid. In order to investigate the treatment and the impact of injected bone cement, an integrated modelling and simulation framework has been developed. The framework includes (i) the generation of microstructural computer models based on microCT images of human cancellous bone, (ii) computational fluid dynamics (CFD) simulations of bone cement injection into the trabecular structure and (iii) non-linear finite element (FE) simulations of the subsequent bone cement curing. A detailed description of the material behaviour of acrylic bone cements is provided for both simulation stages. A non-linear process-dependent viscosity function is chosen to represent the bone cement behaviour during injection. The bone cements phase change from a highly viscous fluid to a solid is described by a non-linear viscoelastic material model with curing dependent properties. To take into account the distinctive temperature dependence of acrylic bone cements, both material models are formulated in a thermo-mechanically coupled manner. Moreover, the corresponding microstructural CFD- and FE-simulations are performed using thermo-mechanically coupled solvers. An application of the presented modelling and simulation framework to a sample of human cancellous bone demonstrates the capabilities of the presented approach. (C) 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim