Electrospun healthcare nanofibers from medicinal liquor of Phellinus igniarius
Electrospun healthcare nanofibers from medicinal liquor of Phellinus igniarius
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桑黄药液静电纺丝保健纳米纤维
DOI：
10.1007/s42114-022-00551-x
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发表时间：
2022-09-10
影响因子：
20.1
通讯作者：
Lu, Xuhua
中科院分区：
文献类型：
--
作者：
Jiang, Wenlai;Zhang, Xinyi;Lu, Xuhua
虽然在这个纳米时代，医疗保健市场每年有数十亿美元的贸易，但用于医疗保健的纳米产品仍然有限。本研究以聚乙烯吡咯烷酮为药物形成基质和药物载体，以桑黄为原料药进行了探索。采用同轴静电纺丝技术将传统保健品（药酒）从PI转化为纳米保健品，即药用核壳纳米纤维。采用自制的聚四氟乙烯涂层同轴静电纺丝装置。揭示了核-壳纳米结构的微观形成机理。采用扫描电子显微镜、透射电子显微镜、X射线衍射仪和傅里叶变换红外光谱仪对所制备的核壳纳米纤维进行了表征，结果表明，所制备的核壳纳米纤维具有明显的核壳结构，呈线状形貌。此外，来自PI的活性成分（主要是多糖）以无定形状态存在于纳米纤维中，表明与聚合物基质具有良好的相容性。通过自制方法和离体渗透实验，评价了药物核壳纳米纤维的功能性能，发现其遇水后能迅速溶解释放负载的活性成分，保证了快速渗透效果。本研究开创了传统药酒静电纺核壳保健纳米产品的潜在应用。
Although the healthcare market has billions of dollars in trade every year in this nano era, the nano products for healthcare remain limited. In this study, polyvinylpyrrolidone was used as a filament-forming matrix and drug carrier, and Phellinus igniarius (PI) was explored as a raw medicinal material. Coaxial electrospinning was implemented to transfer a traditional healthcare product (medicinal liquor) from PI into a nano healthcare product, that is, medicinal core-shell nanofibers. A homemade Teflon-coated concentric spinneret was utilized for setting up the coaxial electrospinning apparatus. The microformation mechanism of core-shell nanostructures from the spinneret was disclosed. The prepared core-shell nanofibers were characterized using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy, by which they were demonstrated to have a linear morphology with an evident core-shell structure. In addition, the active ingredients (primarily polysaccharides) from PI were presented in the nanofibers in an amorphous state, indicating good compatibility with the polymeric matrix. Homemade methods and ex vivo permeation tests were explored to evaluate the functional performance of medicinal core-shell nanofibers, which could be quickly dissolved to release the loaded active ingredients when they encountered water and ensured a rapid permeation effect. The present study pioneered a potential application to more people of electrospun core-shell healthcare nano products from traditional medicinal liquor.