The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.
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Age-1 和 daf-2 基因在控制秀丽隐杆线虫寿命的共同途径中发挥作用。
DOI：
10.1093/genetics/141.4.1399
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发表时间：
1995
期刊：
影响因子：
3.3
通讯作者：
Kenyon,C
中科院分区：
文献类型：
--
作者：
Dorman,JB;Albinder,B;Shroyer,T;Kenyon,C
daf-2和age-1这两个基因的隐性突变显着延长了秀丽隐杆线虫的寿命。 daf-2 基因还调节称为 dauer 的替代发育状态的形成。在这里，我们询问这两个基因是否在相同或不同的寿命途径中发挥作用。我们发现age-1和daf-2突变体的长寿需要相同的两个基因daf-16和daf-18的活性。此外，daf-2(e1370)； Age-1(hx546)双突变体的寿命并不比daf-2单突变体显着长。我们还发现，与 daf-2 突变一样，age-1(hx546) 突变也会影响 dauer 形成的某些方面。这些发现表明，age-1 和 daf-2 突变确实在相同的寿命途径中发挥作用，并通过触发相似（如果不相同）的过程来延长寿命。
Recessive mutations in two genes, daf-2 and age-1, extend the lifespan of Caenorhabditis elegans significantly. The daf-2 gene also regulates formation of an alternative developmental state called the dauer. Here we asked whether these two genes function in the same or different lifespan pathways. We found that the longevity of both age-1 and daf-2 mutants requires the activities of the same two genes, daf-16 and daf-18. In addition, the daf-2(e1370); age-1(hx546) double mutant did not live significantly longer than the daf-2 single mutant. We also found that, like daf-2 mutations, the age-1(hx546) mutation affects certain aspects of dauer formation. These findings suggest that age-1 and daf-2 mutations do act in the same lifespan pathway and extend lifespan by triggering similar if not identical processes.