Analysis of 24-hour urine parameters as it relates to age of onset of cystine stone formation.
Analysis of 24-hour urine parameters as it relates to age of onset of cystine stone formation.
复制标题
分析 24 小时尿液参数，因为它与胱氨酸结石形成的发病年龄有关。
DOI：
10.1089/end.2010.0133
复制
发表时间：
2010
影响因子：
2.7
通讯作者：
N. Miller
中科院分区：
文献类型：
--
作者：
E. Lambert;J. Asplin;S. Herrell;N. Miller
介绍
胱氨酸尿症是一种遗传性疾病，其特征是肾单位近端小管中的二元氨基酸胱氨酸的重吸收受损。胱氨酸结石最常发生在生命的第一至第三十年，老年发病率下降。我们假设，与早期出现结石事件的患者相比，年龄较大的首次出现结石事件的患者24小时尿液参数更有利。
患者
本文回顾性分析94例接受24小时尿液检查的胱氨酸尿症及胱氨酸结石患者。根据首次临床结石事件的年龄将患者分为4组：第1组，年龄<18岁的儿童（n = 37）;第2组，18至32岁（n = 19）;第3组，33至50岁（n = 19）;第4组，>50岁（n = 19）。在任何药物治疗之前收集所有24小时尿液。采用方差分析和Tukey成对比较检验进行统计学分析。
结果
与老年人（第3组和第4组）相比，年轻人（第2组）的胱氨酸过饱和度（SS）显著增加，但各组之间的胱氨酸排泄量无差异。较高的尿量似乎是老年人胱氨酸SS较低的原因。发现儿童具有与年轻成人相似的胱氨酸SS。
讨论
在这项回顾性研究中，发现胱氨酸结石的发病年龄与24小时尿参数之间存在相关性。与较早出现结石的患者相比，年龄较大时首次出现结石的胱氨酸尿患者的胱氨酸SS较低，尿量增加，可能具有保护作用。
INTRODUCTION
Cystinuria is an inherited disorder characterized by the impaired reabsorption of the dibasic amino acid, cystine, in the proximal tubule of the nephron. Cystine stones most frequently occur in the first through third decades of life with a decreased incidence in old age. We hypothesize that patients presenting with first stone event at an older age would have more favorable 24-hour urine parameters compared with those patients who present early.
PATIENTS
This is a retrospective review of 94 patients with cystinuria and cystine stones who underwent a 24-hour urine test. The patients were divided into four groups based on age at first clinical stone event: group 1, children aged <18 years (n = 37); group 2, 18 to 32 years (n = 19); group 3, 33 to 50 years (n = 19); and group 4, >50 years (n = 19). All 24-hour urines were collected prior to any medical therapy. Statistical analysis was performed using analysis of variance and Tukey pairwise comparison test.
RESULTS
There was a significant increase in cystine supersaturation (SS) for the young adults (group 2) as opposed to older adults (groups 3 and 4) though cystine excretion was not different among the groups. A higher urine volume appeared to account for the lower cystine SS in the older adults. The children were found to have cystine SS similar to the young adults.
DISCUSSION
In this retrospective study, a correlation was found between the age of onset of cystine stones and 24-hour urine parameters. Cystinuric patients presenting with first stone event at an older age have lower cystine SS and increased urinary volume compared with patients presenting earlier, likely conferring a protective effect.
评估尿液中胱氨酸的溶解度和异质成核。
DOI：
10.1016/s0022-5347(17)52543-4
发表时间：
1983
期刊：
The Journal of urology
影响因子：
--
作者：
Pak,CY;Fuller,CJ
通讯作者：
Fuller,CJ
一种改良的氰化物-硝普钠方法，用于定量尿胱氨酸浓度，校正肌酐干扰。
DOI：
10.1016/s0009-8981(99)00159-x
发表时间：
1999
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Nakagawa,Y;Coe,FL
通讯作者：
Coe,FL