Circadian clock, cancer, and chemotherapy.
Circadian clock, cancer, and chemotherapy.
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DOI：
10.1021/bi5007354
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发表时间：
2015-01-20
期刊：
影响因子：
2.9
通讯作者：
Ozturk, Nuri
中科院分区：
文献类型：
--
作者：
Sancar, Aziz;Lindsey-Boltz, Laura A.;Gaddameedhi, Shobhan;Selby, Christopher P.;Ye, Rui;Chiou, Yi-Ying;Kemp, Michael G.;Hu, Jinchuan;Lee, Jin Hyup;Ozturk, Nuri
生物钟是一个全球调节系统，与哺乳动物生物体中的大多数其他调节系统和途径相互作用。对生物钟与 DNA 损伤反应关系的研究表明，核苷酸切除修复、DNA 损伤检查点和细胞凋亡明显受到生物钟的影响。尽管一些人类流行病学研究和有限数量的小鼠模型系统遗传学研究表明，生物钟紊乱可能使哺乳动物易患癌症，但对小鼠进行良好控制的遗传学研究并不支持生物钟紊乱是癌症危险因素这一普遍观点。事实上，在适当的遗传背景下，时钟破坏可能通过促进内在和外在的细胞凋亡来帮助癌症消退。最后，时钟可能通过调节化疗药物的药代动力学和药效学以及修复抗癌药物引起的 DNA 损伤的 DNA 修复酶的活性来影响癌症治疗（计时化疗）的功效。
The circadian clock is a global regulatory system that interfaces with most other regulatory systems and pathways in mammalian organisms. Investigations of the circadian clock–DNA damage response connections have revealed that nucleotide excision repair, DNA damage checkpoints, and apoptosis are appreciably influenced by the clock. Although several epidemiological studies in humans and a limited number of genetic studies in mouse model systems have indicated that clock disruption may predispose mammals to cancer, well-controlled genetic studies in mice have not supported the commonly held view that circadian clock disruption is a cancer risk factor. In fact, in the appropriate genetic background, clock disruption may instead aid in cancer regression by promoting intrinsic and extrinsic apoptosis. Finally, the clock may affect the efficacy of cancer treatment (chronochemotherapy) by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
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DOI：
10.1126/science.1203430
发表时间：
2011-06-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cotta-Ramusino C;McDonald ER 3rd;Hurov K;Sowa ME;Harper JW;Elledge SJ
通讯作者：
Elledge SJ
DOI：
10.1073/pnas.0409897102
发表时间：
2005-03-01
影响因子：
11.1
作者：
Gorbacheva, VY;Kondratov, RV;Antoch, MP
通讯作者：
Antoch, MP
影响因子：
16
作者：
Gery, S;Komatsu, N;Koeffler, HP
通讯作者：
Koeffler, HP
影响因子：
11.2
作者：
Gauger, MA;Sancar, A
通讯作者：
Sancar, A
影响因子：
4.3
作者：
Antoch, Marina P.;Gorbacheva, Victoria Y.;Nikitin, Alexander Yu
通讯作者：
Nikitin, Alexander Yu