Cooling and rewarming for brain ischemia or injury: Theoretical analysis
Cooling and rewarming for brain ischemia or injury: Theoretical analysis
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DOI：
10.1114/1.1554924
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发表时间：
2003-03-01
影响因子：
3.8
通讯作者：
Wang, H
中科院分区：
文献类型：
--
作者：
Diao, CG;Zhu, L;Wang, H
本研究建立了一个三维模型来研究选择性脑冷却（SBC）和随后的复温过程中大脑的瞬态和稳态温度分布。选择性的大脑冷却可以通过戴上冷却头盔或用冰块包裹头部来实现。通过将血液灌注率降低到正常值的20%来模拟脑缺血区域。每一层的几何、热特性和生理特性，以及动脉血液温度，都被用作Pennes生物热方程的输入。我们的数据表明，脑灰质的快速冷却可以通过头部表面的SBC来实现（成人26分钟，婴儿15分钟）。在大多数商用冷却头盔中，头部表面和冷却剂之间的不理想热接触被怀疑是SBC中与冰填料相比延迟冷却的主要原因。该研究还表明，在去除冷却源后，通过将头部暴露在室温下模拟的3度/h被动再暖速率可能太快。(C) 2003生物医学工程学会。(DOI: 10.1114/1.1554924)。
A three-dimensional model is developed in this study to examine the transient and steady state temperature distribution in the brain during selective brain cooling (SBC) and subsequent rewarming. Selective brain cooling is induced through either wearing a cooling helmet or packing the head with ice. The ischemic region of the brain is simulated through reducing the blood perfusion rate to 20% of its normal value. The geometric and thermal properties and physiological characteristics for each layer, as well as the arterial blood temperature, are used as the input to the Pennes bioheat equation. Our data suggest that rapid cooling of the brain gray matter can be achieved by SBC on the head surface (26 min for adults versus 15 min for infants). Suboptimal thermal contact between the head surface and the coolant in most commercially available cooling helmets is suspected to be the main reason for delayed cooling in SBC as compared to the ice packing. The study has also demonstrated that the simulated 3degreesC/h passive rewarming rate by exposing the head to room temperature after removing the source of cooling may be too rapid. (C) 2003 Biomedical Engineering Society. [DOI: 10.1114/1.1554924].