Near infrared spectroscopy-measured changes in cerebral blood volume and cytochrome aa in
Near infrared spectroscopy-measured changes in cerebral blood volume and cytochrome aa in
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近红外光谱测量脑血容量和细胞色素氨基酸的变化
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
L. Monteiro
中科院分区：
文献类型：
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作者：
Majidah Shadid;L. Hiltermann;L. Monteiro
目的：验证近红外光谱（NIRS）-测量的脑血容量（DCBV）和细胞色素aa（DCytaa）的变化，作为缺氧和高碳酸血症期间新生羔羊脑灌注和氧合变化的估计值，以及额外的低血压。方法和材料：在33只新生羔羊中，用颈动脉血流量（DQ：ml / min）和脑氧代谢率（DCMR：ml car O2 O / min）测定的脑灌注量与NIRS导出的DCBV（ml / 100 g）和DCytaa（mM）在2 ~ 3低氧、高碳酸血症和额外低血压时的相关性。通过在30分钟内使用6 - 8%O和10%CO通气诱导缺氧和高碳酸血症，并通过小心抽血诱导额外22次低血压（35 mmHg持续5分钟）。结果如下：CBV在缺氧和高碳酸血症期间增加，在额外低血压期间降低，并与DQ相关：（0.009 ml / 100 g变化/ml / min Q：P，0.0001）。Cytaa增加了汽车。在低氧和高碳酸血症期间，CAR 3在随后的额外低血压期间降低，
Objectives: Validation of near infrared spectroscopy (NIRS)-measured changes in cerebral blood volume (DCBV) and cytochrome aa (DCytaa ) as estimators of changes in brain 33 perfusion and oxygenation in the newborn lamb during hypoxia and hypercarbia, and additional hypotension. Methods and materials: In 33 newborn lambs brain perfusion assessed by carotid artery blood flow ( DQ : ml / min)and cerebral metabolic rate of oxygen (DCMR : ml car O2 O / min) were related to NIRS-derived DCBV (ml / 100 g) and DCytaa (mM) during combined 2 3 hypoxia and hypercarbia and additional hypotension. Combined hypoxia and hypercapnia was induced by ventilation with 6‐8% of O and 10% of CO during 30 min, and additional 22 hypotension ( , 35 mmHg for 5 min) was induced by careful withdrawal of blood. Results: CBV increased during hypoxia and hypercarbia, decreased during additional hypotension and was related to DQ : (0.009 ml / 100 g change per ml / min Q : P , 0.0001). Cytaa increased car. car 3 during hypoxia and hypercarbia, decreased during subsequent additional hypotension and