Characterizing dispersion in microfluidic channels.

Characterizing dispersion in microfluidic channels.
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DOI:
10.1039/b822948c
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发表时间:
2009-09-07
期刊:
影响因子:
6.1
通讯作者:
Ghosal S
Ghosal S
中科院分区:
工程技术1区
文献类型:
--
作者:
Datta S;Ghosal S

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分析物条带的分散或扩散是在微流体分离中实现高分辨率的障碍。分散在分离中的作用进行了审查,重点是指标,来源和分析的共同原则。详细研究了三种分散源:(a)非均匀流场,(B)溶质壁相互作用和(c)垂直于通道壁的力场。微流体和纳米流体应用毛细管电泳,色谱和场流分馏,这是受到一个或多个这三个物理过程在标准的,无意的或新的操作条件下,进行了讨论。
Dispersion or spreading of analyte bands is a barrier to achieving high resolution in microfluidic separations. The role of dispersion in separations is reviewed with emphasis on metrics, sources and common principles of analysis. Three sources of dispersion (a) inhomogeneous flow fields, (b) solute wall interactions and (c) force fields normal to channel walls are studied in detail. Microfluidic and nanofluidic applications to capillary electrophoresis, chromatography and field-flow fractionation, that are subject to one or more of these three physical processes under standard, unintentional or novel operating conditions, are discussed.
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发表时间: 1956-01-01
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