Severity of liver fibrosis using shear wave elastography is influenced by hepatic necroinflammation in chronic hepatitis patients, but not in cirrhotic patients
Severity of liver fibrosis using shear wave elastography is influenced by hepatic necroinflammation in chronic hepatitis patients, but not in cirrhotic patients
复制标题
在慢性肝炎患者中，使用剪切波弹性成像的肝纤维化严重程度受肝脏坏死性炎症的影响，但在肝硬化患者中不受影响
DOI：
10.1111/hepr.13617
复制
发表时间：
2021-02-25
影响因子：
4.2
通讯作者：
Iijima, Hiroko
中科院分区：
文献类型：
--
作者：
Nakano, Chikage;Nishimura, Takashi;Iijima, Hiroko
目的 慢性肝病患者的剪切波弹性成像（SWE）是诊断肝纤维化严重程度的一种无创有效方法，可以替代肝活检。然而，使用 SWE 进行的肝脏硬度测量可能会受到多种因素的影响，包括肝脏炎症、肝外胆汁淤积、心力衰竭和潜在的肝脏疾病。本研究的目的是从血清学和病理学角度阐明SWE肝脏硬度与肝脏坏死性炎症之间的相关性。方法对843例接受肝活检的慢性肝病患者进行分析。在肝活检的同一天使用瞬态弹性成像（TE）和虚拟触摸定量（VTQ）进行肝脏硬度测量。从血清学和病理学角度分析SWE与肝脏炎症的相关性。结果随着肝纤维化和炎症的进展，肝脏硬度值显着增加（总体p<0.001）。 F0-1、F2、F3患者中，A2或A3的TE和VTQ值显着高于A0或A1（p值，全部=70 IU/L）显着高于ALT患者
Aim Shear wave elastography (SWE) in patients with chronic liver diseases is a noninvasive useful method for the diagnosis of liver fibrosis severity, which can be an alternative to liver biopsy. However, the liver stiffness measurement using SWE can be affected by various factors including hepatic inflammation, extrahepatic cholestasis, heart failure, and underlying liver diseases. The aim of this study is to clarify the correlation between liver stiffness using SWE and hepatic necroinflammation serologically and pathologically.Methods A total of 843 patients with chronic liver disease who received liver biopsy were analyzed. Liver stiffness measurement using transient elastography (TE) and virtual touch quantification (VTQ) were carried out on the same day as the liver biopsy. The correlation between SWE and hepatic inflammation was analyzed serologically and pathologically.Results The liver stiffness values increased significantly with the progression of liver fibrosis and inflammation (overall p < 0.001). In patients with F0-1, F2, and F3, TE and VTQ values of A2 or A3 were significantly higher than those of A0 or A1 (p value, all = 70 IU/L were significantly higher than those in patients with ALT