Emerging roles of non-coding RNAs in the metabolic reprogramming of tumor-associated macrophages
Emerging roles of non-coding RNAs in the metabolic reprogramming of tumor-associated macrophages
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DOI：
10.1016/j.imlet.2021.02.003
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发表时间：
2021-02-15
影响因子：
4.4
通讯作者：
Su, Zhaoliang
中科院分区：
文献类型：
--
作者：
Li, Jiali;Lu, Zhenyi;Su, Zhaoliang
巨噬细胞是肿瘤微环境中最常见的免疫细胞，肿瘤相关巨噬细胞在肿瘤的发生发展中起着重要作用。代谢重编程对巨噬细胞的功能可塑性很重要。对非编码RNA(NcRNAs)在人类癌症中相关性的研究发现，ncRNAs可以调节癌细胞和肿瘤相关巨噬细胞的代谢。NcRNAs包括短ncRNAs、长ncRNAs(LncRNAs)和环状RNAs(CircRNAs)。最常见的短ncRNAs是microRNAs，它通过作用于代谢相关的途径和靶向代谢相关的酶和蛋白质来调节巨噬细胞中的葡萄糖、脂肪和氨基酸代谢，因此参与了癌症的进展。LncRNAs和CircRNAs在肿瘤相关巨噬细胞代谢中的作用尚不清楚。LncRNAs影响巨噬细胞的葡萄糖代谢，但其在脂质和氨基酸代谢中的作用尚不清楚。CircRNAs调节巨噬细胞的氨基酸代谢。NcRNAs在能量代谢中的作用及其机制有待进一步研究。在这里，我们总结了最近关于ncRNAs参与肿瘤相关巨噬细胞代谢重新编程的研究结果，这些重新编程影响肿瘤微环境，并在癌症的发展中发挥重要作用。提高我们对ncRNAs在肿瘤相关巨噬细胞代谢重编程中的作用的了解，可能有助于开发有效的临床治疗方法。
Macrophages are the most common immune cells in the tumor microenvironment, and tumor-associated macrophages play an important role in cancer development. Metabolic reprogramming is important for the functional plasticity of macrophages. Studies investigating the relevance of non-coding RNAs (ncRNAs) in human cancer found that ncRNAs can regulate the metabolism of cancer cells and tumor-associated macrophages. NcRNAs include short ncRNAs, long ncRNAs (lncRNAs), and circular RNAs (circRNAs). The most common short ncRNAs are microRNAs, which regulate glucose, lipid, and amino acid metabolism in macrophages by acting on metabolism-related pathways and targeting metabolism-related enzymes and proteins, and are therefore involved in cancer progression. The role of lncRNAs and circRNAs in the metabolism of tumor-associated macrophages remains unclear. LncRNAs affect the glucose metabolism of macrophages, whereas their role in lipid and amino acid metabolism is not clear. CircRNAs regulate amino acid metabolism in macrophages. The roles of ncRNAs in energy metabolism and the underlying mechanisms need to be investigated further. Here, we summarize recent findings on the involvement of ncRNAs in metabolic reprogramming in tumor-associated macrophages, which affect the tumor microenvironment and play important roles in the development of cancer. Improving our understanding of the effects of ncRNAs on metabolic reprogramming of tumor-associated macrophages may facilitate the development of effective clinical therapies.