Growth failure associated with early neglect: pilot comparison of neglected US children and international adoptees.
Growth failure associated with early neglect: pilot comparison of neglected US children and international adoptees.
复制标题
DOI：
10.1515/jpem-2014-0231
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Brady KT
中科院分区：
文献类型：
--
作者：
Miller BS;Spratt EG;Himes JH;Condon D;Summer A;Papa CE;Brady KT
不同的忽视环境对儿童成长的长期影响还没有得到很好的研究。三组儿童，3-10岁，被招募（n = 60）：以前制度化的国际被收养者生活在稳定的家庭环境中至少2年（IA; n = 15），在美国出生的忽视历史的儿童（USN; n = 17），和控制（n = 28）。儿童进行体格检查，人体测量，并收集血清生长参数。平均身高标准差评分（SDS）不同（p < 0.05）。IAs中的头围（HC）显著较小（p < 0.05）。胰岛素生长因子（IGF-1）是生长激素作用的标志物，在美国被忽视的儿童中较高。对照组和US忽视组之间经年龄和体重SDS校正的IGF-1存在差异（p < 0.05）。IAs儿童身高和HC的生长障碍程度比被忽视的美国儿童更严重。这些发现可能反映了慢性和间歇性剥夺对生长激素系统的影响之间的差异。
The long-lasting impact of different neglectful environments on growth in children is not well studied. Three groups of children, 3–10 years old, were recruited (n = 60): previously institutionalized international adoptees living in stable home environments for at least 2 years (IA; n = 15), children with a history of neglect born in the USA (USN; n = 17), and controls (n = 28). Children underwent physical examination, anthropometry, and collection of serum for growth parameters. Mean height standard deviation scores (SDS) were different (p < 0.05). Age-adjusted head circumference (HC) was significantly smaller (p < 0.05) in IAs. Insulin growth factor (IGF-1), a marker of growth hormone action, was higher in US neglected children. IGF-1 adjusted for age and weight SDS were different (p < 0.05) between control and US neglect groups. The degree of growth failure in height and HC in IAs was more severe than neglected US children. These findings may reflect differences between the impact of chronic and intermittent deprivation on the growth hormone system.