POSSIBILITY OF LATENT CENTROMERES AND A PROPOSED NOMENCLATURE SYSTEM FOR TOTAL CHROMOSOME AND WHOLE ARM TRANSLOCATIONS
POSSIBILITY OF LATENT CENTROMERES AND A PROPOSED NOMENCLATURE SYSTEM FOR TOTAL CHROMOSOME AND WHOLE ARM TRANSLOCATIONS
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DOI：
10.1159/000130497
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发表时间：
1975-01-01
期刊：
影响因子：
--
通讯作者：
CHEN, TR
中科院分区：
文献类型：
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作者：
HSU, TC;PATHAK, S;CHEN, TR
涉及整个染色体或整个染色体臂的易位可能不一定需要缺失着丝粒。可以想象，在着丝粒或端粒融合或着丝粒与端粒融合的过程中，可能发生着丝粒失活，从而在所得易位染色体中保留两个着丝粒-一个功能性的，另一个潜伏的。如果这种潜在的着丝粒存在，并且能够被重新激活，这将解释如何在染色体分裂或断裂的反向过程中获得额外的功能性着丝粒。一个系统的命名法，提出了确定这些染色体重排的起源和性质。
Translocations involving entire chromosomes or whole chromosome arms may not necessarily require deletion of a centromere. Conceivably, in the process of centromeric or telomeric fusion or of fusion of a centromere with a telomere, centromeric inactivation may occur, thus preserving both centromeres—one functional, the other latent—in the resultant translocation chromosome. If such latent centromeres exist and, in addition, are capable of being reactivated, it would explain how additional functional centromeres are acquired in the reverse process of chromosomal fission or fragmentation. A system of nomenclature is proposed for identifying the origin and nature of these chromosomal rearrangements.