Steroidogenic factor 1 (SF-1) is essential for ovarian development and function
Steroidogenic factor 1 (SF-1) is essential for ovarian development and function
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DOI：
10.1016/s0303-7207(99)00237-3
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发表时间：
2000-05-25
影响因子：
4.1
通讯作者：
Parker, KL
中科院分区：
文献类型：
--
作者：
Hanley, NA;Ikeda, Y;Parker, KL
孤儿核受体类固醇生成因子1（SF-1）最初被确定为细胞色素P450类固醇羟化酶组织特异性表达的关键调节因子。SF-1在小鼠胚胎中的表达模式分析提示了其更广泛的作用。正如预期的那样，SF-1在肾上腺和性腺发育的早期阶段就表达。令人惊讶的是，SF-1也在垂体前叶和下丘脑的主要类固醇生成组织外表达。SF-1基因敲除小鼠在体内戏剧性地证实了它的多种重要作用。这些小鼠缺乏肾上腺和性腺，导致肾上腺皮质功能不全和内外生殖器的雄性到雌性的性别逆转。SF-1基因敲除小鼠垂体促性腺激素表达受损，下丘脑腹内侧核（VMH）发育不全，证实了SF-1在下丘脑-垂体-性腺轴所有三个水平的作用。随着卵巢的一些重点，这篇综述总结了SF-1在内分泌发育中的重要作用的实验，并强调了未来研究的重要领域。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
The orphan nuclear receptor steroidogenic factor 1 (SF-1) was identified originally as a key regulator of the tissue-specific expression of the cytochrome P450 steroid hydroxylases. Hints at considerably broader roles for SF-1 came from analyses of its expression pattern in mouse embryos. As anticipated, SF-1 was expressed in the adrenal glands and gonads from their early stages of development. Surprisingly, SF-1 also was expressed outside of the primary steroidogenic tissues in the anterior pituitary and hypothalamus. SF-1 knockout mice dramatically confirmed its multiple essential roles in vivo. These mice lacked adrenal glands and gonads, leading to adrenocortical insufficiency and male-to-female sex reversal of their internal and external genitalia. SF-1 knockout mice also had impaired pituitary expression of gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic-pituitary-gonadal axis. With some focus on the ovary, this review summarizes experiments that have defined essential roles of SF-1 in endocrine development, and highlights important areas for future studies. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.