Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms
Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms
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DOI：
10.1001/archpsyc.64.3.356
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发表时间：
2007-03-01
影响因子：
--
通讯作者：
Lehtimaki, Terho
中科院分区：
文献类型：
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作者：
Jokela, Markus;Keltikangas-Jarvinen, Liisa;Lehtimaki, Terho
背景：基因-环境相互作用被认为与抑郁症的发展有关。目的：确定血清素受体 2A (HTR2A) 基因是否调节儿童母亲养育与成年抑郁症状之间的关联。设计：一项为期 21 年的前瞻性纵向研究，对自变量和因变量进行 2 次测量。背景：基于人群的样本。参与者：年轻芬兰人心血管风险研究的 1212 名参与者的子样本研究的基线年龄为 3 至 18 岁。主要结果指标：成年期抑郁症状。结果：携带 HTR2A 基因 T102C 多态性的 T/T 或 T/C 基因型的个体对养育母亲的保护方面有反应，因此在母亲养育较高的情况下，他们表现出较低水平的抑郁症状，而 C/C 基因型携带者则不然。结论： HTR2A 基因可能通过影响个体利用环境支持的能力而参与抑郁症的发生。
Background: Gene-environment interactions are assumed to be involved in the development of depression.Objective: To determine whether the serotonin receptor 2A (HTR2A) gene moderates the association between childhood maternal nurturance and depressive symptoms in adulthood.Design: A 21-year, prospective, longitudinal study with 2 measurements of the independent and dependent variables.Setting: A population-based sample.Participants: A subsample of 1212 participants of the Cardiovascular Risk in Young Finns study, aged 3 to 18 years at baseline.Main Outcome Measure: Depressive symptoms in adulthood.Results: Individuals carrying the T/T or T/C genotype of the T102C polymorphism of the HTR2A gene were responsive to the protective aspects of nurturing mothering, so that in the presence of high maternal nurturance, they expressed low levels of depressive symptoms, while this was not true with the carriers of the C/C genotype.Conclusion: The HTR2A gene may be involved in the development of depression by influencing the ability of individuals to use environmental support.