Role of mentholated cigarettes in increased nicotine dependence and greater risk of tobacco-attributable disease
Role of mentholated cigarettes in increased nicotine dependence and greater risk of tobacco-attributable disease
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DOI：
10.1016/j.ypmed.2004.01.019
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发表时间：
2004-06-01
影响因子：
5.1
通讯作者：
Falkner, RV
中科院分区：
文献类型：
--
作者：
Garten, S;Falkner, RV
背景。冷空气刺激上呼吸道冷感受器，导致呼吸活动的反射抑制作用。低浓度的薄荷醇也能刺激这些冷感受器，对呼吸活动产生抑制作用。薄荷香烟在吸食时，会释放足够的薄荷醇来刺激冷感受器，从而使吸烟者体验到一种“凉爽的感觉”。薄荷醇吸烟者所经历的“清凉感”会导致呼吸活动的反射抑制效应。文献检索是在NLM数据库中完成的(例如，MEDLINE from 1966， TOXLINE, OLDMEDLINE (1985-1965)， CANCERLIT，以及烟草行业文献和硬拷贝索引。将证据应用于薄荷烟吸烟进行评价。结果和讨论。本文提出了一个合乎逻辑的发展框架，以证明薄荷香烟中的薄荷醇可能导致呼吸抑制，从而导致更多地暴露于烟草烟雾中的有毒物质。由于冷感受器的刺激导致屏气，因此更有可能暴露并将肺部内容物转移到肺循环中。对于薄荷吸烟者来说，这会导致他们更多地接触到尼古丁和吸烟时产生的颗粒物（焦油）。这种接触可导致尼古丁依赖增加和烟草引起疾病的更大机会。(C) 2004癌症预防研究所和爱思唯尔公司。版权所有。
Background. Cold air stimulates upper airway cold receptors causing a reflex depressive effect on respiratory activity. Menthol, in low concentrations can also stimulate these same cold receptors causing a depressive effect on respiratory activity. Menthol cigarettes when smoked, deliver enough menthol to stimulate cold receptors resulting in the smoker experiencing a "cool sensation." The "cool sensation" experienced by the menthol smoker can result in a reflex-depressive effect on respiratory activity.Method. Literature searches were done for the NLM databases (e.g., MEDLINE from 1966, TOXLINE, OLDMEDLINE (1985-1965), CANCERLIT, plus tobacco industry documents and hardcopy indices. The evidence was evaluated with application to mentholated cigarette smoking.Results and Discussion. A logical progression is presented that develops the framework to prove that menthol found in mentholated cigarettes may cause respiratory depression resulting in greater exposure to the toxic substances found in tobacco smoke.Conclusion. As a result of breath holding that results from the stimulation of cold receptors there is a greater opportunity for exposure and transfer of the contents of the lungs to the pulmonary circulation. For the menthol smoker this results in a greater exposure to nicotine and the particulate matter (tar) of the smoked cigarette. This exposure can result in increased nicotine dependence and greater chance of tobacco-attributable disease. (C) 2004 The Institute For Cancer Prevention and Elsevier Inc. All rights reserved.