ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions.
ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions.
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DOI：
10.1097/iae.0000000000002258
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发表时间：
2019-10
期刊：
影响因子：
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通讯作者：
Freeman WR
中科院分区：
文献类型：
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作者：
Meshi A;Chen KC;You QS;Dans K;Lin T;Bartsch DU;Cheng L;Amador-Patarroyo MJ;Muftuoglu IK;Gomez ML;Nudleman E;Freeman WR
目的应用光学相干断层扫描血管造影（OCTA）和中央视觉分析仪（CVA）评估无糖尿病视网膜病变（DR）临床证据的糖尿病患者早期视网膜微血管和功能改变。这是一项在无DR的糖尿病患者和非糖尿病对照组中进行的观察性病例对照研究。患者接受OCTA成像和使用CVA的视力测试。用盲法测量视网膜中央凹无血管区（FAZ）面积和浅、深毛细血管丛毛细血管密度（CD）。35例糖尿病患者的60只眼被纳入研究组，31例非糖尿病患者的45只眼被纳入对照组。糖尿病组与对照组FAZ面积无显著性差异（均p > 0.05）。与对照眼相比，糖尿病眼深毛细血管丛的平均CD显著较低（p = 0.04）。与对照组相比，糖尿病患者所有CVA模块的平均视力均显著降低（所有p < 0.05）。OCTA能够检测到深毛细血管丛中的视网膜微血管变化，CVA显示出在无DR的糖尿病患者中模拟次优对比度和眩光的条件下视力下降的迹象。
To assess early retinal microvascular and functional changes in diabetic patients without clinical evidence of diabetic retinopathy (DR) with optical coherence tomography angiography (OCTA) and central visual analyzer (CVA). This was an observational case-control study of diabetic patients without DR and non-diabetic controls. Patients underwent OCTA imaging and visual acuity testing using the CVA. The foveal avascular zone (FAZ) area and the capillary density (CD) in the superficial and deep capillary plexuses were measured manually by a masked grader. Sixty eyes from 35 diabetic patients were included in the study group and 45 eyes from 31 non-diabetic patients were included in the control group. FAZ area was not significantly different between the diabetic group and controls (both p > 0.05). The mean CD in the deep capillary plexus was significantly lower in diabetic eyes compared with control eyes (p = 0.04). The mean visual acuity in all CVA modules was significantly decreased in diabetic patients compared with controls (all p < 0.05). OCTA was able to detect retinal microvascular changes in the deep capillary plexus and the CVA showed signs of decreased visual acuity under conditions simulating suboptimal contrast and glare in diabetic patients without DR.