Vancomycin resistance in gram-positive cocci
Vancomycin resistance in gram-positive cocci
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DOI：
10.1086/491711
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发表时间：
2006-01-01
影响因子：
11.8
通讯作者：
Courvalin, P
中科院分区：
文献类型：
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作者：
Courvalin, P
1988年，欧洲首次报道了肠球菌属的万古霉素耐药临床分离株。后来在美国东海岸的医院也发现了类似的菌株。从那时起，耐万古霉素肠球菌以意想不到的速度传播，现在大多数国家的医院都遇到过这种情况。本文综述了细菌对糖肽类耐药的作用方式和机制，以VanA型为例，该型由转座子Tn1546介导，在肠球菌中广泛传播。然后讨论了耐甲氧西林金黄色葡萄球菌的多样性、调节、进化和最近的传播。
The first vancomycin-resistant clinical isolates of Enterococcus species were reported in Europe in 1988. Similar strains were later detected in hospitals on the East Coast of the United States. Since then, vancomycin-resistant enterococci have spread with unexpected rapidity and are now encountered in hospitals in most countries. This article reviews the mode of action and the mechanism of bacterial resistance to glycopeptides, as exemplified by the VanA type, which is mediated by transposon Tn1546 and is widely spread in enterococci. The diversity, regulation, evolution, and recent dissemination of methicillin-resistant Staphylococcus aureus are then discussed.